On the Role of the Cytokines in Mechanisms Responsible for Nephropathies
Abstract
Cytokines are considered to be the key factors in the mechanisms resposible for the different pathological processes. We investigated the blood level of two cytocines (TNF-β and IGF-1) in 45 children with chronic pyelonephritis. All the children were divided into four groups. The first group consisted of 13 children with acute pyelonephritis. The second group consisted of 7 children with an exacerbation of chronic pyelonephritis. The third group consisted of 13 patients with vesicoureteric reflux without any symptoms of active urinary tract infection. The patients of the fourth group (14 children) had the chronic non-obstructive pyelonephritis. The blood level of TNF-β and IGF-1 was estimated by means of DRG IGF-1 ELSA KIT and R&D TNF-β KIT. The blood level of both cytokines was the highest in the third group. It reached 131, 6 ± 4,7 pg/ml in this group and was significantly higher than in three others groups (p < 0,05). The IGF-1 blood level was the lowest in the first group. We suppose that the increase in TNF-β and IGF-1 blood level in children with vesicoureteric reflux may be connected mechanisms responsible for reflux nephropathy.
About the Authors
S. S. Paunova
НИИ педиатрии НЦЗД РАМН, Российский Государственный Медицинский Университет, Москва
Russian Federation
Russian Federation
A. G. Kucherenko
НИИ педиатрии НЦЗД РАМН, Российский Государственный Медицинский Университет, Москва
Russian Federation
Russian Federation
Ch. M. Markov
НИИ педиатрии НЦЗД РАМН, Российский Государственный Медицинский Университет, Москва
Russian Federation
Russian Federation
References
1. Панаян А., Савенкова Н. Клиническая нефрология детского возраста. С.П., СОТИС, 1997.
2. The 33 Annual Meeting of ESPN sept. 1999; Abstracts. - Ped Nephrol 1999; 13; 7: 15-98.
3. Ваrratt M., Avner E., Harmon W. Pediatric Nephrology. - 4th ed. - Lippincott Williams & Wilkins, 1999; 1412.
4. The 11 th Congress of IPNA Sept. 1998 Abstracts. Ped Nephrol 1998; 12;7: 27-222.
5. Dinarello C., Wolf S. The role of interleukine - 1 in disease. - N Engl J Med 1993; 328: 106-13.
6. Dinarello C. The proinflammatory cytokines interleukine - 1 and tumor necrosis factor and treatment of the septic shock syndrome. - J Inf Dis 1991; 163: 1177-84.
7. Eddy A. Growth factors in interstitial diseases. - Ped Nephrol1998; 12; 7: 41.
8. Snick van J. Interleukine-6: an overview. - Annu Rev Immunol 1990; 8: 253-78
9. Schroder J. Inerleukine -8. Adv Neuroimmuno l992; 2: 109-24.
10. Ruddle N. in The Cytokine Handbook. - A. Thompson, ed., Academic Press, NY, 1994; 305.
11. Tullus K. Mechanisms of renal damage in UTI,- Ped Nephrol 1998;12;7: 39.
12. Tullus K. et al. Soluble receptors to tumor necrosis factor and interleukine-6 in urine during acute pyelonephritis.-Acta Paediatr 1997; 86; 1198-1202.
13. Tullus K. et al. lnterleukine-la and interleukine-l receptor antagonist in the urine of children with acute pyelonephritis and relation to renal scarring.-Acta Paediatr 1996: 85; 158-62.
14. Rovin B. Chemokines as therapeutic targets in renal inflammation.-Am J Kidney Dis 1999; 34; 4: 761-767.
Review
For citations:
Paunova S.S., Kucherenko A.G., Markov Ch.M. On the Role of the Cytokines in Mechanisms Responsible for Nephropathies. Nephrology and Dialysis. 1999;1(2-3):141-143. (In Russ.)
Views:
10
Email this article 