Is Rapid Acetylation a Predictor of Kidney and Urinary Tract Diseases
Abstract
Acetylation processes play an essential role in metabolism. Their phenotypes are now considered to be the geneti cally determined ability of the organism to metabolize compounds containing amino groups. In this study, acetyli tion was studied in 156 children aged from three to 15 years. 97 of them showed clinical evidences of differeii nephropathies. In 59 children there were only minimal urinary changes, but they were residents of regions with soi contaminated by high levels of heavy metals. A special aim of the study was to investigate whether the acetylation tesi could be used to predict kidney or urinary tract diseases in children living in environments with high contents oi heavy metals salts. Rapid acetylation prevailed both in patients with different nephropathies and in children froi regions with high heavy metals contamination, even if they had only mild urinary abnormality. We suggest that thi acetylatation test can be used to predict kidney or urinary tract diseases in ecologically unfavorable conditions.
About the Authors
Zn. Kh. Soblirova
МНИИ педиатрии и детской хирургии МЗ РФ, отделение наследственных и приобретенных болезней почек
Russian Federation
Russian Federation
E. A. Kharina
МНИИ педиатрии и детской хирургии МЗ РФ, отделение наследственных и приобретенных болезней почек
Russian Federation
Russian Federation
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Review
For citations:
Soblirova Z.Kh., Kharina E.A. Is Rapid Acetylation a Predictor of Kidney and Urinary Tract Diseases. Nephrology and Dialysis. 1999;1(1):20-23. (In Russ.)
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