Cytochemical Analysis of Peripheral Blood Lymphocites in Children with Chronic Glomerulonephritis Treated witn Corticosteroids
Abstract
The aim of the study was to investigate the effect of corticosteroids (Cs) on the mitochondrial succinate degydrogenase activity (MSDGA) of peripheral blood lymphocites in patients with glomerulonephritis. MSDGA was evaluated by a quantitative cytochemical method in three groups of patients. The first group was treated with Cs pulses, and the second with oral Cs. Patients in the third group went into remission and were therefore not treated. The results of the study confirmed the effect of Cs on the enzyme status of peripheral blood lymphocytes. The changes of MSDGA evaluated in the beginning of therapy correlated with treatment protocol. They were maximal after Cs pulses (1st group) and significantly lower in patients who received oral Cs (2nd group). In the third group, MSDGA was normal. A relationship was found between the changes in MSDGA after the first Cs pulse and the reduction ofproteinuria by the seventh day of treatment.
About the Authors
O. V. Komarova
Научный центр здоровья детей РАМН, Москва
Russian Federation
Russian Federation
T. V. Sergeeva
Научный центр здоровья детей РАМН, Москва
Russian Federation
Russian Federation
V. M. Schischenko
Научный центр здоровья детей РАМН, Москва
Russian Federation
Russian Federation
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Review
For citations:
Komarova O.V., Sergeeva T.V., Schischenko V.M. Cytochemical Analysis of Peripheral Blood Lymphocites in Children with Chronic Glomerulonephritis Treated witn Corticosteroids. Nephrology and Dialysis. 1999;1(1):81-85. (In Russ.)
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