Cardiac remodeling and pulmonary hypertension in haemodialysis patients
Abstract
Aim: Pulmonary hypertension (PH) is a risk factor for mortality and cardiovascular events in hemodialysis patients. The aim of this study was to investigate cardiac remodeling and pulmonary blood pressure during a year-long hemodialysis treatment. Methods: Fifty patients (F-31, M-19, mean age 55±12 years) were studied in the beginning of hemodialysis and after a year. Echocardiography and Doppler echocardiography were performed. Pulmonary hypertension was diagnosed according to European Society of Cardiology Guidelines. Results: Pulmonary hypertension was revealed in 29 (58%) patients. After a year of dialysis treatment, the left ventricular mass decreased from 159.1±35.8 to 129.1±42.2 g/m2 (р=0.04) and systolic pulmonary blood pressure decreased from 46.3±16.1 to 40.4±11.7 mmHg (р=0.01). There is no relationship between the pulmonary blood pressure and blood flow in arteriovenous fistula (r=0.12, р=0.3). Pulmonary pressure correlated negatively with the left ventricular ejection fraction. Conclusions: Pulmonary hypertension in hemodialysis patients is associated with the left ventricular hypertrophy and systolic and diastolic dysfunction of left ventricular. After a yearlong hemodialysis treatment, a regress in left ventricular hypertrophy and a partial decrease in pulmonary blood pressure were observed.
About the Authors
S. A. Karpunin
Kirov Regional Clinical Hospital
Russian Federation
Russian Federation
E. O. Borodulina
Kirov Regional Clinical Hospital
Russian Federation
Russian Federation
A. M. Shutov
Ulyanovsk State University
Russian Federation
Russian Federation
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For citations:
Karpunin S.A., Borodulina E.O., Shutov A.M. Cardiac remodeling and pulmonary hypertension in haemodialysis patients. Nephrology and Dialysis. 2016;18(1):62-68. (In Russ.)
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