Dynamics of cystatin C and serum interleukin-18 level in children with lymphoma

Abstract

Aim. The purpose of our research was the determination of cystatin C (СysC) and interleukin-18 level alongside with the known AKI markers: serum creatinine, GFR, examination at three-stages of treatment of inpatient children with lymphomas: at original admission of a child to the inpatient department, on the background of intensive polychemotherapy and upon the completion of therapy. Materials and methods. 40 patients with newly diagnosed lymphoma in the period from 01/2008 till 01/2014 were included into the study. Results. The serum creatinine level for children with lymphomas at the background of chemotherapy averaged 0.88±0.19 mg%, and was significantly higher than before the start and after the completion of intensive therapy. The level of СysC in blood before the therapy was 0.92±0.22 mg/l. At the background of intensive treatment it increased to 1.36±0.48 mg/l, and remained at the level of 1.30±1.10 mg/l when the intensive therapy was completed. The average level of interleukin-18 in serum of patients with lymphomas was 525.02±106.44 pg/ml before therapy. At the background of intensive therapy it increased to 963±196.14 pg/ml with the subsequent decrease to 759±277.63 pg/ml during the period of remission of the main disease. Conclusion. Thus, we have detected an increase in СysC and interleukin-18 levels for children with lymphomas at the background of intensive polychemotherapy compared to the periods before and after the treatment. These indicators could be used for prediction of development of toxic AKI.