Generalised oedema. Pathogenesis and treatment
Abstract
The lecture concentrates on the analysis of mechanisms of development of oedema in cardiac failure, in renal and hepatic diseases. Additionally, the mechanisms of the development of the drug-induced and idiopathic oedema are reviewed. General approaches to the treatment of oedema are introduced including the management of diuretic-refractory oedema. It is concluded that in the chain of events underlying pathogenesis of oedema of varying genesis, antinatriuretic mechanisms strongly prevail upon diuretic ones. Despite different ways of kidney involvement, enhanced renal sodium reabsorption is a common link in the formation of oedema of various origins, and even in advanced stages of renal disease kidney is capable to actively retain sodium.
About the Authors
Ya. Yu. Bagrov
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, St. Petersburg, Russia
Russian Federation
Russian Federation
N. B. Manusova
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Science, St. Petersburg, Russia
Russian Federation
Russian Federation
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Review
For citations:
Bagrov Ya.Yu., Manusova N.B. Generalised oedema. Pathogenesis and treatment. Nephrology and Dialysis. 2011;13(4):388-395. (In Russ.)
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