Methods of approach to elucidation of calcium homeostasis failure mechanisms after kidney transplantation
Abstract
The influence of renal tubular calcium reabsorption on calcium homeostasis was studied in 28 healthy volunteers with normo- and hypercalcaemia (during v/v calcium gluconate infusion), 36 kidney allograft recipients with fasting hypercalcaemia (10 of them where treated by cyclosporine A, prednisolone and azathyoprine, 26– with prednisolone and azathyoprine) and 17 kidney allograft recipients with fast hypocalcaemia, treated by prednisolone and azathyoprine. Calcium reabsorption was calculated by CaR/GFR (CaUF – CaE/GFR) and T-score CaR/GFR (the difference between CaR/GFR in the recipient and healthy persons at the same CaUF normalized for its standard deviation in healthy people). It was revealed that hypercalcemia in 8 recipients in triple and in 14 recipients in double-component immunosuppression was caused by a combination of increased tubular calcium reabsorption with elevated calcium flow from tissues to blood. In others recipients hypercalcemia resulted from extrarenal reasons.
About the Authors
I. E. Borodulin
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. A. Pronchenko
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
N. P. Shmerko
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. P. Yermakova
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Borodulin I.E., Pronchenko I.A., Shmerko N.P., Yermakova I.P. Methods of approach to elucidation of calcium homeostasis failure mechanisms after kidney transplantation. Nephrology and Dialysis. 2010;12(3):179-183. (In Russ.)
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