Catastrophic antiphospholipid syndrome in young woman with the systemic lupus erythematosus
Abstract
A review of literature on catastrophic antiphospholipid syndrome (CAS) including the basic concepts of pathogenesis, clinical displays, morphological features, diagnostics and treatment is presented. The difference between classical variants of CAS – primary and secondary, at systemic lupus erythematosus, is emphasized. The review is illustrated by a clinical case of a patient with CAS which has developed as the main manifestation of SLE. Some aspects of differential diagnostics of CAS with others microangiopathic syndromes – GUS/TTP and DIC-syndrom – are presented.
Keywords
катастрофический антифосфолипидный синдром (КАФС),
системная красная волчанка (СКВ),
тромботическая тромбоцитопеническая пурпура,
тромботическая микроангиопатия,
ДВС-синдром,
полиорганная недостаточность,
catastrophic antiphospholipid syndrome (CAPS),
systemic lupus erythematosus (SLE),
thrombotic thrombocytopenic purpura,
trombotic microangiopathies,
disseminated intravascular coagulation syndrome
About the Authors
N. L. Kozlovskaya
Moscow Sechenov Medical Academy, chair of nephrology and hemodialysis
Russian Federation
Russian Federation
N. A. Tomilina
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
E. S. Stolyarevich
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
L. S. Birukova
Shumakov Federal Research Center of Transplantology and Artificial Organs, Moscow
Russian Federation
Russian Federation
I. A. Skryabina
Moscow City Hospital № 52
Russian Federation
Russian Federation
E. V. Kalyanova
Moscow State University of Medicine and Dentistry, Russian Federal Health Agency
Russian Federation
Russian Federation
V. V. Varyasin
Moscow City Hospital № 52
Russian Federation
Russian Federation
M. E. Zhukova
Moscow City Hospital № 52
Russian Federation
Russian Federation
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Review
For citations:
Kozlovskaya N.L., Tomilina N.A., Stolyarevich E.S., Birukova L.S., Skryabina I.A., Kalyanova E.V., Varyasin V.V., Zhukova M.E. Catastrophic antiphospholipid syndrome in young woman with the systemic lupus erythematosus. Nephrology and Dialysis. 2010;12(3):208-219. (In Russ.)
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