A clinical-morphological analysis of the medicinal kidney lesions during therapy with non-steroid anti-inflammatory drugs

The patients of specialized hospitals of the Rostov area have been surveyed to analyse medicinal lesions of kidneys treated with non-steroid anti-inflammatory drugs. At the first stage, anamnesis, clinical features and laboratory parameters were analyzed. At the second stage we analyzed morphological changes in kidney biopsy. At the third stage we developed a forecast system of morphological changes to estimate of the risk of the pathology. 21 patients were surveyed (12 M/9 F). The middle age was 39,5 years. 19 patients (90,5%) had high blood pressure; 8 (38,1%) had edema; 9 (42,9%) had delicacy; 7 ones (33,3%) had nausea; 6 (28,6%) had lumbar pains; 2 (9,5%) had headaches; 4 (19,0%) had the high fever; 10 (47,6%) had polyuria. The duration of the disease varied from 2 months to 22 years. The changes of the laboratory parameters were as follows: 14 people (66,7%) had decreased hemoglobin; 7 (33,3%) had a decrease in erythrocytes; 15 (71,4%) had increased the ESR; 17 (81,0%) had hematuria; 19 (90,5%) had proteinuria; 11 ones (52,4%) had leukocyturia; 11 (52,4%) had decreased urea density in the Zimnitsky test. Changes in urine were found in all patients; 14 patients (61,7%) had renal dysfunction estimated by creatinine level. Morphological changes were found in glomeruli, intersticial tissue, tubules and blood vessels. We have obtained equations which allow one to estimate the risk of the development of pathological changes and developed a system of forecasting the risk of morphological changes due to medicinal kidney lesions treated with non-steroid anti-inflammatory drugs.

склероз клубочков, атрофия канальцев, фиброз интерстиция, фиброз артериол, лекарственный интерстициальный нефрит

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