Separated and combined fulfillment of the standard peritoneal equilibration test (PET) and mini-PET

Aim: to assess the possibility to conduct double mini-PET combined with standard PET (peritoneal equilibration test). The combination provides the complete assessment of the peritoneal membrane state during one visit; however, there are doubts whether the short exchange before a standard PET will distort its results. Methods: two standard PET and two combined double mini-PET with standard PET were consequentially performed in 21 stable patients on continuous ambulatory peritoneal dialysis (CAPD). The average patient’s age was 55±10 years; CAPD duration was 37±25 months. Dialysate-to-plasma creatinine ratio after 4-hour exchange (D/P4) differences for combined and performed separately PET were evaluated, accounting for the natural dynamics of peritoneal permeability. Results: the ratio D/P4 in the second separated test was 0.745±0.110, in the first combined test 0.740±0.100; over the time interval between tests (5.0±2.3 months), the average change in the individual values of D/P4 in the pairwise comparison was in terms of semi-annual change of 0.008±0.028. Thus, the systemic bias between the two measurements was 1.2%, and the random was 3.8%. The correlation between test results was 0.957; p<0.001). As part of analyzing the effect of the natural dynamics of peritoneum permeability on changes in the results, the changes in individual data were evaluated for the time interval between two standard and between two combined samples. The change in D/P4 between standard tests was 0.014±0.030 (system bias 1.9%, random bias 4.1%); between the combined tests 0.005±0.056 (system bias 0.7%, the random one 7.6%). Thus, the change in the D/P ratio after changing methods (and over a period of 5 months) did not exceed the natural dynamics of membrane permeability over similar periods when performing the same test. Conclusion: the combination of double mini- and standard PET does not distort the standard PET results, which allows using the capabilities of both test options with a reduction in logistic costs for the patient and dialysis center.

перитонеальный диализ, тест перитонеального равновесия, мини-ПЭТ, peritoneal dialysis, peritoneal equilibration test, mini-PET

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