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Quality of life and associated clinical factors in immune-mediated glomerulopathies

https://doi.org/10.28996/2618-9801-2023-4-541-553

Abstract

Quality of life (QoL) of patients with immune-mediated glomerulopathies (IGP) in pre-dialysis stages of chronic kidney disease is scantily studied. The aim: testing the hypothesis on a relationship between QoL variables, clinical indices of IGP severity, and its “primary” or “secondary” etiology. Patients and methods: the study included 430 patients with primary IGP (IgA nephropathy, minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, membranoproliferative glomerulonephritis/С3 glomerulopathy) and secondary IGP: systemic lupus erythematosus, ANCA-vasculitis, systemic scleroderma, rheumatoid arthritis, plasma cell dyscrasias (amyloidosis/myeloma). All IGP cases were biopsy-proven and immunosuppression naive. For QoL evaluation, we used the Russian version of the Kidney Disease Quality of Life Short Form (KDQOL-SF) questionnaire that comprises general scales and kidney disease-specific scales. Routine clinical and demographic parameters were applied as independent variables in multivariable regression models. Results: QoL indicators were significantly lower in the secondary IGP group compared to the primary IGP. Female gender, an older age, a decrease in serum albumin, estimated glomerular filtration rate, and mean blood pressure as well as secondary IGP etiology and nephrotic syndrome were all independently associated with a decrease in the QoL. Clinical and demographic factors explained 3 to 34% of the variance in QoL in models applied. Conclusion: we confirmed a close association between the etiology of IGP, its clinical features, and QoL indices. Such association should be considered in the planning of personalized management of patients with IGP with baseline evaluation and monitoring of self-assessed QoL.

About the Authors

I. A. Vasilieva
Pavlov University
Russian Federation


E. N. Levykina
Pavlov University
Russian Federation


V. A. Dobronravov
Pavlov University
Russian Federation


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Vasilieva I.A., Levykina E.N., Dobronravov V.A. Quality of life and associated clinical factors in immune-mediated glomerulopathies. Nephrology and Dialysis. 2023;25(4):541-553. (In Russ.) https://doi.org/10.28996/2618-9801-2023-4-541-553

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