The characteristic of glomeruli and value of renal blood flow at rest and following water load in rats during postnatal ontogenesis
Abstract
On the anesthetized Wistar rats in the age of 4, 12, 30 and 65 - days-old the renal blood flow by laser-Doppler flowmetry, and diameter, number and density of glomeruli, diameter of afferent and efferent arterioles were measured. We found out that during rat development the RBF increased 2,8 times, the diameter of glomeruli - 3,6 times, diameter of afferent arterioles - 1,8, and the efferent arterioles - raised 1,3 times. The number of glomeruli increased 1,3 times, but their density decreased 16 times. The renal blood flow was measured in 12-day-old and 65-day-old Wistar rats using laser-Doppler flowmeter to study the response to water load. The basal level of RBF was measured following surgery, and then water load (5% of body weight) was infused into the stomach through the tube. The maximal values were registered during the second hour: RBF increased 31 ± 5,6 and 24 ± 6,6% compare to basal level for 12 and 65-day-old rats. The total renal blood flow during 180 min increased compare to basal level 18% in young and 16% in adult rats.
About the Authors
U. V. Shyyrapai
ГОУ ВПО Новосибирский государственный педагогический университет; Государственное Учреждение Научно-исследовательский институт физиологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. M. Belichenko
Государственное Учреждение Научно-исследовательский институт физиологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
C. A. Shoshenko
Государственное Учреждение Научно-исследовательский институт физиологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
R. I. Aizman
ГОУ ВПО Новосибирский государственный педагогический университет
Russian Federation
Russian Federation
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Review
For citations:
Shyyrapai U.V., Belichenko V.M., Shoshenko C.A., Aizman R.I. The characteristic of glomeruli and value of renal blood flow at rest and following water load in rats during postnatal ontogenesis. Nephrology and Dialysis. 2008;10(1):55-61. (In Russ.)
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