Complement-fixing antibodies to BK virus in kidney transplant recipients
Abstract
BK virus-associated nephropathy caused by reactivation of BK virus is a major reason of allograft loss. In this article we present our findings for complement-fixing antibodies (CFA) to BK virus in kidney transplant recipients, patients on hemodialysis and healthy blood donors. CFA were observed in 63/181 (35%) of kidney transplant recipients, 7/41 (17%) of patients on hemodialysis and in 3/38 (8%) of blood donors. The patients on hemodialysis and blood donors had maximal titers 1:20 whereas the kidney transplant recipients had CFA titers 1:40 or 1:80. We also analyzed the frequency of revealing CFA a function of duration of posttransplant period; it was 45% in group of patients with posttransplant period more than 1 year, and only 16% in group about one year. This work provides the first set of data about BK virus infection in the population of kidney transplant recipients in Russia. The results confirm an existing point of view that there is high frequency of BK virus reactivation in kidney transplant recipients.
About the Authors
I. A. Ezhkov
ФГУ НИИ трансплантологии и искусственных органов Росздрава РФ, Московский городской нефрологический центр, городская клиническая больница № 52; г. Москва
Russian Federation
Russian Federation
I. G. Kim
ФГУ НИИ трансплантологии и искусственных органов Росздрава РФ, Московский городской нефрологический центр, городская клиническая больница № 52; г. Москва
Russian Federation
Russian Federation
A. G. Strokov
ФГУ НИИ трансплантологии и искусственных органов Росздрава РФ, Московский городской нефрологический центр, городская клиническая больница № 52; г. Москва
Russian Federation
Russian Federation
F. S. Baranova
ФГУ НИИ трансплантологии и искусственных органов Росздрава РФ, Московский городской нефрологический центр, городская клиническая больница № 52; г. Москва
Russian Federation
Russian Federation
V. Yu. Abramov
ФГУ НИИ трансплантологии и искусственных органов Росздрава РФ, Московский городской нефрологический центр, городская клиническая больница № 52; г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Ezhkov I.A., Kim I.G., Strokov A.G., Baranova F.S., Abramov V.Yu. Complement-fixing antibodies to BK virus in kidney transplant recipients. Nephrology and Dialysis. 2007;9(2):177-180. (In Russ.)
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