Is the thin basement membrane disease a predisposing factor to others glomerulopathies?
Abstract
The study presents frequency of occurrence, clinical and morphological features of Thin Basement Membrane Nephropathy (TBMN) in children. TBMN was diagnosed using EM ultrastructural morphometry of the kidney biopsy specimens. TBMN was diagnosed in 10 (19,2%) of 52 children subjected to renal biopsy in years 2004-2005 only in one of 10 patients. Other 9 children had TBMN combined with mesangial-proliferative glomerulonephritis. Four patients had IgA-nephropathy, three had nephrotic syndrome. After renal biopsy children with nephrotic syndrome were treated with steroids and immunosuppressive drugs: two with cyclophosphamide, one - with cyclosporine A. All 10 children also were treated with ACE-inhibitors. After the follow up period all children have had microscopic hematuria and mild proteinuria. There were no signs of either nephrotic syndrome or renal progression (mean GFR 97,2 ± 8,2 ml/min). Our preliminary data suggest that TBMN could be predisposition factor for different glomerular diseases.
About the Authors
M. S. Ignatova
ФГУ «МНИИ педиатрии и детской хирургии Росздрава»
Russian Federation
Russian Federation
L. S. Prikhodina
ФГУ «МНИИ педиатрии и детской хирургии Росздрава»
Russian Federation
Russian Federation
E. P. Golitsina
Московская медицинская академия им. И.М. Сеченова; г. Москва
Russian Federation
Russian Federation
V. A. Varshavsky
Московская медицинская академия им. И.М. Сеченова; г. Москва
Russian Federation
Russian Federation
V. V. Dlin
ФГУ «МНИИ педиатрии и детской хирургии Росздрава»
Russian Federation
Russian Federation
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Review
For citations:
Ignatova M.S., Prikhodina L.S., Golitsina E.P., Varshavsky V.A., Dlin V.V. Is the thin basement membrane disease a predisposing factor to others glomerulopathies? Nephrology and Dialysis. 2007;9(2):186-191. (In Russ.)
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