Isolated visceral form of Kaposi’s sarcoma in renal graft recipient. Case report

Kaposi's sarcoma is a limphoangioproliferous tumor described for the first time in 1872 year by Moritz Kaposi. It is a relatively common malignancy after kidney transplantation, generally presents as characteristic dermatomucosal lesions. The frequency of Kaposi’s sarcoma in renal recipients appears to be significantly different in various geographical areas and is about 0.5% (from 0.06% to 4.1%). Visceral organ involvement is common in conjunction with skin lesions; however, isolated visceral Kaposi’s sarcoma is an uncommon disease among renal graft recipients. This report introduces a case of Kaposi’s sarcoma with lungs, lymph nodes, and small intestine involvements. A 53-years-old female renal graft recipient was admitted to our hospital with fever, cough, dyspnea, and diarrhea. The examination revealed pleural effusion and bilateral diffuse lesions in the lungs, intrathoracic and axillary lymphadenopathy, splenomegaly, pancytopenia. There were no specific skin manifestations for Kaposi’s sarcoma, so it was difficult to diagnose. However, the patient had a recurrent widespread maculopapular rash. These symptoms are clinical signs of HHV8-related viremic syndromes. Kaposi’s sarcoma was documented by histopathological evaluation of samples obtained from an axillary lymph node biopsy. Postmortem evaluation also indicated lung and small intestine involvements with Kaposi’s sarcoma. This case illustrates the complexity of diagnosing an isolated visceral form of Kaposi’s sarcoma and the need to exclude it in kidney graft recipients in the absence of dermatomucosal lesions.

саркома Капоши, почечный трансплантат, веретеновидные клетки, 8 тип вируса герпеса человека, Kaposi’s Sarcoma, renal graft, spindle shaped cells, type 8 of human herpes virus

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