Significance of sex hormones in bone mineral losses in women with good graft function in late period after kidney transplantation
Abstract
Bone turnover markers, parathyroid hormone (PTH), spine and hip bone mineral density (BMD) were determined in 56 women receiving triple immunosuppressive therapy with good graft function at 47 ± 35 months after KT. Estradiol, testosterone, sex hormone-binding globulin (SHBG), osteoprotegerin (OPG) and insulin-like growth factor-1 (IGF-1) were estimated in 24 of them (15 in premenopause and 9 in postmenopause). Bone turnover disturbances (increased resorption and normal or decreased formation), hip BMD-losses, lowered level of total and free testosterone, SHBG and IGF-1 were similar in pre- and postmenopause women. Axial BMD-losses were more pronounced in postmenopause women, and correlated with lower estradiol and higher PTH and OPG levels. Axial bone losses in women after KT correlated with PTH and SHBG (inverse correlations) and with free estradiol (direct correlation). Apart from PTH and SHBG, hip bone losses correlated directly with the total and free testosterone.
About the Authors
I. A. Pronchenko
ФГУ «НИИ трансплантологии и искусственных органов» Росздрава, г. Москва
Russian Federation
Russian Federation
V. P. Buzulina
ФГУ «НИИ трансплантологии и искусственных органов» Росздрава, г. Москва
Russian Federation
Russian Federation
N. A. Tomilina
ФГУ «НИИ трансплантологии и искусственных органов» Росздрава, г. Москва
Russian Federation
Russian Federation
R. N. Vedernikova
ФГУ «НИИ трансплантологии и искусственных органов» Росздрава, г. Москва
Russian Federation
Russian Federation
I. P. Yermakova
ФГУ «НИИ трансплантологии и искусственных органов» Росздрава, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Pronchenko I.A., Buzulina V.P., Tomilina N.A., Vedernikova R.N., Yermakova I.P. Significance of sex hormones in bone mineral losses in women with good graft function in late period after kidney transplantation. Nephrology and Dialysis. 2006;8(3):254-259. (In Russ.)
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