Study of glycated hemoglobin level in diabetes mellitus patients subjected to programmed hemodialysis
Abstract
Level of glycated hemoglobin (HbA1c) as indicator of hyperglycemia have been investigated in patients with diabetes mellitus types I and with EsRD on programmed hemodialysis. In 19 patients with diabetes mellitus type I and in 13 patients with diabetes mellitus type II the following parameters were investigated: glucose, hemoglobin, HbA1c, creatinine and urea. The levels of glucose and HbA1c were higher in patients with diabetes mellitus type I compared to type II. In patients with diabetes mellitus type I with glycemia level above 10 mmol/l, the HbA1c content does not reflect actual hyperglycemia. In patients with diabetes mellitus type II on programmed hemodialysis the blood HbA1c increases proportionally to blood glucose concentration.
About the Authors
A. V. Pushkina
ООО «Компания «Фесфарм», центр экстракорпоральной терапии
Russian Federation
Russian Federation
T. P. Vavilova
Московский государственный медико-стоматологический университет, кафедра биохимии, г. Москва
Russian Federation
Russian Federation
A. I. Mordik
ООО «Компания «Фесфарм», центр экстракорпоральной терапии
Russian Federation
Russian Federation
T. A. Fesyuk
Московский государственный медико-стоматологический университет, кафедра биохимии, г. Москва
Russian Federation
Russian Federation
References
1. Добронравов В.А. Эпидемиология диабетической нефропатии: общие и региональные проблемы. Нефрология 2002; 6 (1): 16-22.
2. Маршалл В.Дж. Клиническая биохимия. М.-СПб.: «Издательство БИНОМ» - «Невский диалект», 1999: 368.
3. Практические рекомендации по лечению анемии. European Renal Association-European Dialysis Transplant Association. 2001: 8-9.
4. Физиология системы крови. Физиология эритропоэза. Под ред. В.Н. Черниговского. Л.: Наука, 1979: 359.
5. Anonimus. Fresenius Medical Care. ESRD Patients in 2003. A Global Perspective: 3-9.
6. Feest T.G., Dunn E.J., Burton C.J. Can intensive treatment alter the progress of established diabetic nephropathy to end-stage renal failure? J Med 1999; 92: 275-282.
7. Flauto R.P., Janeen B.L., Sehgal A.R. The provision and outcomes of diabetic care of haemodialysis patients. Am J Kidney Dis 2003, Jan; 41; 1б: 125-131.
8. Garel M.S., Blonquit J. et al. HbA1c: a review on its structure, byosintesis, clinical significance and methods of assey. Biomedicine 1979; 30; 5: 234-240.
9. Joy M.S., Cefalu W.T. et al. Long-term glycemic control measurements in diabetic patients receiving hemodialysis. Am J Kidney Dis 2002, Feb; 39 (2): 297-307.
10. Labie D., Wajemann H. et al. Glicosylation non-enzimatique de hemoglobine chez le sujet normale et diabetique. Cr Soc Biol 1979; 173: 321-330.
11. Lippert J., Ritz E. et al. The rising tide of end stage renal failure from diabetic nephropathy type II - an epidemiological analysis. Nephrol Dial Transplant 1995; 10: 462-467.
12. Little R.R., Tennill A.L. Can glycohemoglobin be used to assess glycemic control in patients with chronic renal failure? Clin Chem 2002; 48 (5): 784-786.
13. Mai-Szu Wu, Chun-Chen Yu et al. Poor pre-dialysis glicaemic control is a predictor of mortality in type II diabetic patient on maintenance haemodialysis. Nephrol Dial Transplant 1997; 12: 2105-2110.
14. Maiza H., Thomas M.-J., Dorcely A. Survival of end stage renal disease diabetic patients on hemodialysis. Nephrol Dial Transplant 2004; 18 (Suppl. 4): 124.
15. Marioka T., Emoto М. et al. Glycemic Control Is a predictor of survival for diabetic patients on hemodialysis. Diabetes Care 2001; 24: 909-913.
16. Mc Murray S.D. The challenges of diabetes care in the dialysis unit. Semin Dial 2003; 16 (3): 197-198.
17. McMurray S.D., Johnson G. et al. Diabetes education and care management significantly improve patient outcomes in the dialysis unit. Am J Kidney Dis 2002; 40 (3): 566-575.
18. Reda Ghacha, Ajit Kumar Sinha, Ayman M. Karkar. HbA1c and Serum Fructosamine as Markers of the Chronic Glycemic State in Type 2 Diabetic Hemodialysis Patients. Dialysis&Transplantation 2001; 30 (4): 214-217.
19. Samaja M., Melotti D. et al. Glucosylated haemoglobins and the oxygen affinity of whote blood. Diabetologia 1982; 23; 5: 339-402.
Review
For citations:
Pushkina A.V., Vavilova T.P., Mordik A.I., Fesyuk T.A. Study of glycated hemoglobin level in diabetes mellitus patients subjected to programmed hemodialysis. Nephrology and Dialysis. 2005;7(2):157-161. (In Russ.)
Views:
8
Email this article 