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Content of blood and urinary NO in CGN patients with different degree of arterial hypertension, inflammatory process and tubulointerstitial component

Abstract

The aim of the study was determining the nitric oxide (NO) concentration in blood plasma and urine in patients with chronic glomerulonephritis (CGN) and arterial hypertension (AH) at different stages of inflammatory process and different severity of tubulointerstitial component (TIC). Twenty five patients (18 males and 7 females, average age 39,2 ± 2,04 years) were surveyed. The mesangioproliferative GN was diagnosed in all patients, TIC was found in 20 patients. In all patients and 20 healthy donors plasma and urine NO concentration was determined by the method of Golikov et al. (2000). In CGN patients with AH syndrome NO increased. The highest blood NO level was found in patients with inactive form of disease, especially those with TIC (22,5 ± 1,9 and 31,3 ± 2,5 µM/l, respectively). Activation of CGN was accompanied by a moderate increase of NO level (16,5 ± 1,9 and 15,9 ± 2,1 µM/l). Excretion of NO with urea in inactive stage of disease was increased compared to its acute stage (10,2 ± 1,9 and 13,1 ± 1,9 µM/l, respectively). In CGN patients with TIC it was even higher (15,3 ± 2,8 µM/l). High blood level of NO is characteristic for inactive phase of CGN. TIC is a significant factor determining the NO balance between blood and urea in CGN patients.

About the Authors

E. A. Movchan
Новосибирская государственная медицинская академия
Russian Federation


N. V. Volvich
ГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. Новосибирск
Russian Federation


L. B. Kim
ГУ Научный центр клинической и экспериментальной медицины СО РАМН, г. Новосибирск
Russian Federation


N. L. Tov
Новосибирская государственная медицинская академия
Russian Federation


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Review

For citations:


Movchan E.A., Volvich N.V., Kim L.B., Tov N.L. Content of blood and urinary NO in CGN patients with different degree of arterial hypertension, inflammatory process and tubulointerstitial component. Nephrology and Dialysis. 2005;7(4):463-467. (In Russ.)

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ISSN 1680-4422 (Print)
ISSN 2618-9801 (Online)