Apoptosis - physiology and pathology
Abstract
Apoptopsis (programmed cell death) occurs normally for maintenance of a tissue homeostasis and plays an important role in morphogenesis, embryogenesis and tissue growth. On the other hand apoptosis may be involved in different pathological processes such as malignancy, infectious diseases and autoimmune disorders. Apoptosis is regulated by various mediators. Caspases, death receptors, mitochondria, Bcl-2 protooncogenes and tumor suppressor genes are considered to be the most important of them. Advances in apoptosis regulation research suggest new options for therapy of wide range of human pathologies.
About the Author
S. S. Paunova
Российский государственный медицинский университет, Москва
Russian Federation
Russian Federation
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Review
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Paunova S.S. Apoptosis - physiology and pathology. Nephrology and Dialysis. 2004;6(2):132-137. (In Russ.)
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