Use of immunomodulator levamisole in treatment of children with steroid-dependent and frequently relapse nephrotic syndrome
Abstract
Fifteen children with steroid-dependent (SD) and frequently relapsing (FR) nephrotie syndrom (NS) were treated with levamisole (1,7-2,5 mg/kg/48 h) for 3 to 19 months. The duration of remission from the beginning of levamisole treatment, duration of remission after cancellation of levamisole and prednisolone, frequency of relapse before and after treatment, and cumulative dose of prednisolone during 6 months before and during immunomodulate therapy were estimated. Sighificant decrease in frequency of relapse and duration of remission was shown in children with FR NS levamisole compared to patients with SD NS. Our preliminary data suggest that levamisole is very efficient in children with FR NS.
About the Authors
S. V. Papij
МНИИ педиатрии и детской хирургии МЗ РФ, г. Москва
Russian Federation
Russian Federation
E. V. Fokeeva
МНИИ педиатрии и детской хирургии МЗ РФ, г. Москва
Russian Federation
Russian Federation
E. A. Rujitskaya
МНИИ педиатрии и детской хирургии МЗ РФ, г. Москва
Russian Federation
Russian Federation
O. Y. Turpitko
МНИИ педиатрии и детской хирургии МЗ РФ, г. Москва
Russian Federation
Russian Federation
O. V. Katysheva
МНИИ педиатрии и детской хирургии МЗ РФ, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Papij S.V., Fokeeva E.V., Rujitskaya E.A., Turpitko O.Y., Katysheva O.V. Use of immunomodulator levamisole in treatment of children with steroid-dependent and frequently relapse nephrotic syndrome. Nephrology and Dialysis. 2004;6(1):58-61. (In Russ.)
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