Pulse wave velocity and aortic compliance in patients on maintenance hemodialysis: relationship with risk factors, cardiac calcification and intracardial hemodynamics
Abstract
Decreasing elasticity of arterial wall is common among the ERSD patients, that results in disturbance of damping arterial function, affects the hemodynamics and contributes in left ventricular (LV) hypertrophy, diastolic dysfunction, morbidity and mortality. Pulse wave velocity (PWV) is the integral parameter that reflects the elasticity of arteries. The aim of the study was to investigate the influence of eventual risk factors on the aortic compliance, as well as the impact of PWV on the patients survival. In prospective observation study we examine 157 pts. on maintenance hemodialysis, 77 fem. and 88 males, age 48,5 ± 0,97, dialysis vintage 45,0 ± 3,6 months. PWV was determined by original method on standard ultrasound device with 1 Doppler sensor, placed in aorta projection close to celiac trunk. PWV M ± Sd was 5,73 (med. 5,4) ± 1,7 (from 3,2 до 17 m/s). Calcium score (CS), DAP, Hb level, max Ca × PO4, EF и Ca max (м), Ca max, PO4, PTH (f). We found correlation between CS and PWW (r = 0,44, p < 0,05). In conclusion, PWV and Ve/Va (reflect the diastolic function of LV) were independent predictors of mortality in patients on maintenance hemodialysis.
About the Authors
Yu. N. Perecokin
кафедра госпитальной терапии № 2 РГМУ, г. Москва
Russian Federation
Russian Federation
V. Yu. Shilo
Центр диализа при ГКБ № 20
Russian Federation
Russian Federation
G. E. Gendlin
кафедра госпитальной терапии № 2 РГМУ, г. Москва
Russian Federation
Russian Federation
A. Yu. Denisov
Центр диализа при ГКБ № 20
Russian Federation
Russian Federation
G. E. Storozhakov
кафедра госпитальной терапии № 2 РГМУ, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Perecokin Yu.N., Shilo V.Yu., Gendlin G.E., Denisov A.Yu., Storozhakov G.E. Pulse wave velocity and aortic compliance in patients on maintenance hemodialysis: relationship with risk factors, cardiac calcification and intracardial hemodynamics. Nephrology and Dialysis. 2004;6(1):62-69. (In Russ.)
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