Preview

Nephrology and Dialysis

Advanced search

Peritoneal dyalisis: early predictors of late outcomes

Abstract

The aim of the study was to reveal the effect of some clinical and biochemical parameters, patient age and comorbide status on the late result of peritoneal dialysis (PD). 277 patients with ESRD were followed-up. The patients were divided into two groups: 148 patients with successful outcome (continued PD by the end of the follow-up period or those who had kidney transplantation) and unsuccessfully treated patients (died or those who was switched to HD). The late outcome was estimated by survival rate of patients and PD technique. Regression model of Cox was used for calculation of relative death risk. We show that the comorbidity index (M.E. Charlson) is a reliable predictor of the late outcome of PD. Unfavourable risk factors were high permeability of peritoneum and hypoalbuminemia in the beginning of the PD treatment. A decrease in albumin level by 1 g/l below 36 g/l increased the risk of death by a factor of 1,1. It was also shown that the survival rate for diabetics was much lower in comparison with non-diabetic patients.

About the Authors

A. M. Andrusev
Московский городской нефрологический центр, городская клиническая больница № 52, г. Москва
Russian Federation


N. L. Titova
Московский городской нефрологический центр, городская клиническая больница № 52, г. Москва
Russian Federation


B. T. Bikbov
Московский городской нефрологический центр, городская клиническая больница № 52, г. Москва
Russian Federation


N. A. Tomilina
Московский городской нефрологический центр, городская клиническая больница № 52, г. Москва
Russian Federation


References

1. Avram M.M., Mittman N., Bonomini L., Chattopadhyay J., Fein P. Markers for survival in dialysis: A seven-year prospective study. Am J Kidney Dis 1995; 26: 209-219.

2. Blumenkrantz M.J. Nutrition in: Daugirdas J.T., Ing T.S. (eds.): Handbook of Dialysis (ed 2). Boston, Little, Brown, 1994.

3. Blake P.G., Flowerdew G., Blake R.M., Oreopoulus D.G. Serum albumin in patients on continuous ambulatory peritoneal dialysis: Predictors and correlations with clinical outcomes. J Am Soc Nephrol 1993; 3: 1501-1507.

4. Beddhu S., Bruns F.J., Saul M., Seddon P., Zeidel M.L. A simple comorbidity scale predicts clinical outcomes and cost in dialysis patients. Am J Med 2000; 108: 609-613.

5. Charlson M.E., Pompei P., Ales K.L., MacKenzie C.R. A new method of classifying prognostic comorbidity in longitudinal stidies: Development and validation. J Chron Dis 1987; 40: 373-383.

6. Churchill D.N., Thorpe K.E., Vonesh E.F., Keshaviah P.R., for the Canada-USA (CANUSA) Peritoneal Dialysis Study Group: Lower probability of survival with continuous peritoneal dialysis in the United States compared with Canada. J Am Soc Nephrol 1997; 8: 965-971.

7. Churchill D.N., Thorpe K.E., Nolph K.D., Keshaviah P.R., Oreopoulus D.G., Page D. Increased peritoneal transport is associated with decreased patients and technique survival for continuous ambulatory peritoneal dialysis patients. J Am Soc Nephrol 1998; 9: 1285-1292.

8. Chung S.H., Chu W.S., Lee H.A., Kim Y.H., Lee I.S., Lindholm B., Lee H.B. Peritoneal transport characteristics, comorbid diseases and survival in CAPD patients. Perit Dial Int 2000; 20: 544-547.

9. Davies S.J., Bryan J., Phillips L., Russell G.I. The predictive value of Kt/V and peritoneal solute transport in CAPD patients is dependent on the type of comorbidity present. Perit Dial Int 1996; 16 (Suppl 1): S158-S162.

10. Davies S.J., Phillis L., Griffiths A.M., Russel L.H., Naish P.F., Russel G.I. What really happens to people on long-term peritoneal dialysis? Kidney Int 1998; 54: 2207-2217.

11. Fried L., Bernardini J., Piraino B. Charlson comorbidity index as a predictor of outcomes in incident peritoneal dialysis patients. Am J Kidney Dis 2001; 37: 337-342.

12. Fried L., Bernardini J., Piraino B. Neither size nor weight predicts survival in peritoneal dialysis patients. Perit Dial Int 1996; 16: 357-361.

13. Fried L. High membrane permeability predict poorer patients survival. Perit Dial Int 1997; 17: 387-401.

14. Fenton S.S.A., Shaubel D.E., Desmeules W., Morrison S.I., Moa Y., Copleston P. et al. Heamodialysis versus peritoneal dialysis: a comparison of adjusted mortality rates. J Am Soc Nephrol 1997: 30: 334-342.

15. Ikizler T.A., Hakim R.M. Nutrition in end-stage renal disease. Kidney Int 1996; 50: 343-357.

16. Kaysen G.A., Silang R., Regalado M., Cheng T.H., Wesson D.E. Prokinetic agents increase plasma albumin in hypoalbuminemic chronic dialysis patients with delayed gastric emptying. Am J Kidney Dis 2001; 37; 2: 287-293.

17. Kawaguchi Y. Peritoneal dialysis as long-term treatment: comparison of technique survival between asian and western populations. Perit Dial Int 1999; 19 (Suppl 2): 327-328.

18. Krediet R.T., Zweers M.M., van der Wal A.C., Struijk D.G. Neoangiogenesis in the peritoneal membrane. Perit Dial Int 2000; 20 (Suppl 2): 19-25.

19. Leavey S.F., Strawderman R.L., Jones C.A., Port F.K., Held P.J. Simple nutritional indicators as independent predictors of mortality in hemodialysis patients: Am J Kidney Dis 1998; 31: 997-1006.

20. Longenecker J.C., Coresh J., Klag M.J., Levey A.S., Martin A.A., Fink N.E., Powe N.R., for the CHOICE Study: Validation of comorbid conditions on End-Stage Renal Disease Medical Evidence Report: The Choice Study. J Am Soc Nephrol 2000; 11: 520-529.

21. Levey A.S., Meyer K.B., Athienites N.V., Marsh J.V., Martin A.A., Miskulin D.C., Fink N.E., Coresh J., Powe N.R., Klag M.J., CHOICE Study: Comparison of comorbidity in incident peritoneal dialysis and hemodialysis patients in the CHOICE Study. J Am Soc Nephrol 1999; 10: 248A.

22. Lo W.K., Tong K.L., Li C.S., Chan T.M., Wong Andrew K.M., Ho Y.W., Cheung K.O., Kwan T.H., Shing K.W., Ng Flora S.K., Cheng Ignatius KP: Relationship between adequacy of dialysis and nutritional status, and their impact on patient survival on CAPD in Hong Kong. Perit Dial.

23. Menkus M.P., Jager K.J., Dekker F.W., de Haan R.J., Boeschoten E.W., Krediet R.T., for the NECOSAD Study Group. Predictors of poor outcome in chronic dialysis patients: the Netherlands Cooperative Study on the adequacy of dialysis. Am J Kidney Dis 2000; 35: 69-79.

24. Rocco M.V., Frankenfield D.L., Prowant B., Frederick P., Flanigan M.J. Risk factors for mortality in U.S. peritoneal dialysis patients: impact of residual renal function. Perit Dial Int 2002; 22: 371-379.

25. Rossert J.A., Wauters J.-P. Recommendations for the screening and management of patients with chronic kidney disease. NDT 2002; (Suppl 1): 19-28.

26. Silang R., Regalado M., Cheng T.H., Wesson D.E. Prokinetic agents increase plasma albumin in hypoalbuminemic chronic dialysis patients with delayed gastric emptying. Am J Kidney Dis 2001; 37; 2: 287-293.

27. Twardowski Z.J., Nolph K.D., Khanna R. et al. Peritoneal equilibration test. Peritoneal Dialysis Bulletin Inc 1987: 138-147.

28. US Renal Data System: USRDS 2001, Annual Data Report. Bethesda, MD, National Institutes of Health, National Institutes of Diabetes and Digestive and Kidney Diseases, 2001.

29. Wang T., Heimbuger O., Cheng H.H., Bergstrom J., Lindholm B. Does a high peritoneal transport rate reflect a state of chronic inflammation? Perit Dial Int 1999; 19: 17-22.

30. Wu C.H., Huang C.C., Huang J.Y., Wu M.S., Leu M.L. High-flux peritoneal membrane is a risk factor in survival of CAPD patients. Adv Perit Dial 1996; 12: 105-109.


Review

For citations:


Andrusev A.M., Titova N.L., Bikbov B.T., Tomilina N.A. Peritoneal dyalisis: early predictors of late outcomes. Nephrology and Dialysis. 2003;5(4):362-368. (In Russ.)

Views: 6


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1680-4422 (Print)
ISSN 2618-9801 (Online)