Acute renal injury in newborns with malformations treated in the department of neonatal surgery of the federal perinatal center

Objective: to determine the incidence of AKI among survivors of the Department of surgery and intensive care of newborns and to determine the effect of asphyxia, the presence of heart disease, circulatory failure on the incidence of AKI in a group of children. Methods: a retrospective study of 314 patients who were treated in the neonatal surgery department in the period from 2006 to 2018 was performed. Patients were divided into groups according to the main diagnosis: gastroschisis, diaphragmatic hernia, omphalocele, pulmonary adenomatosis, esophageal, duodenal, small intestine atresia, VACTERL association. Criteria of exclusion: less than 2 biochemical blood tests for 48 hours or 7 days, lethal outcome. The gender of the child, birth weight, gestational age, the degree of asphyxia at birth, the presence of congenital heart disease, the degree of circulatory disorders, the degree of AKI, the day of life when AKI was detected, the day of life when surgery was performed. KDIGO neonatal classification criteria were used to determine the degree of AKI. Results: AKI was found in 93 (29.6%) newborns: AKI 1 in 66 newborns (21% of the total number of children in the study), AKI 2 in 23 (7.3%), AKI 3 in 4 (1.3%) cases. In most cases, AKI in patients with surgical pathology was detected on 2-3 day of life. We have found that low body weight and premature birth are AKI predictors in children with esophageal atresia. It has also been demonstrated that low body weight is a predictor of AKI in children with omphalocele.

острое почечное повреждение, ОПП, новорожденные, неонатальная хирургия, acute kidney injury, AKI, neonate, neonatal surgery

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