Some pathogenetic factors of progression of chronic glomerulonephritis in children
Abstract
In order to investigate the role of tumor necrosis factor-α and interferon-γ in pathogenesis of tubulointerstitial damage we examined 21 children with chronic glomerulonephritis. In all of them the blood levels of tumor necrosis factor-α and interferon-γ were measured by immunoenzyme assay and renal biopsy was made. We found dependence between the blood level of tumor necrosis factor-α and interferon-γ in children with chronic glomerulonephritis and the degree of the tubulointerstitial damage, was more important the role of these factors in the pathogenesis of tubulointerstitial changes in early period of diseases (on the stage of the influx of inflammatory cells in the renal interstitium).
About the Authors
N. N. Kartamysheva
НИИ педиатрии НЦЗД РАМН, г. Москва
Russian Federation
Russian Federation
A. G. Kucherenko
НИИ педиатрии НЦЗД РАМН, г. Москва
Russian Federation
Russian Federation
O. V. Chumakova
НИИ педиатрии НЦЗД РАМН, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Kartamysheva N.N., Kucherenko A.G., Chumakova O.V. Some pathogenetic factors of progression of chronic glomerulonephritis in children. Nephrology and Dialysis. 2003;5(1):48-51. (In Russ.)
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