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Results of four years multicenter study of the Sundimmun Neoral efficacy in children with nephrotic syndrome

Abstract

There was four-years multicenter study of the Sandimmun Neoral (Novartis Pharma, Switzerland) efficacy in nephrological departments of Moscow, Ekaterinburg, Samara, Novosibirsk (Russia) and Alma-Ata (Kazakhstan). One hundred and two children with NS were treated by unique protocol of using of Sandimmun Neoral. Fifty three patients had steroid-sensitive nephrotic syndome (SSNS), 49 children was steroid-resistant (SRNS). Kidney biopsy was produced in 20 children with SSNS and 31 with SRNS. Duration of the NS before the start of Sandimmun Neoral treatment was from 1 to 10 years. Maximal dose was 5 mg/kg/24 h. Maximal cyclosporin blood level was 150 ng/ml. High grade of efficacy of Sandimmun Neoral was shown as in children with SSNS as in patients suffered by SRNS. Positive effect was noted in different morphological variants of glomerulonephritis. It was shown the possibility to appear of cyclosporin-dependency in some children with NS.

About the Authors

M. S. Ignatova
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


E. A. Kharina
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


O. Yu. Turpitko
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


V. A. Obukhova
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


N. A. Korovina
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


N. A. Chruscheva
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


G. A. Makovezkaja
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


M. K. Soboleva
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


A. B. Kanatbayeva
гг. Москва, Екатеринбург, Самара, Новосибирск (Россия), Алма-Ата (Казахстан)
Russian Federation


References

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Review

For citations:


Ignatova M.S., Kharina E.A., Turpitko O.Yu., Obukhova V.A., Korovina N.A., Chruscheva N.A., Makovezkaja G.A., Soboleva M.K., Kanatbayeva A.B. Results of four years multicenter study of the Sundimmun Neoral efficacy in children with nephrotic syndrome. Nephrology and Dialysis. 2003;5(2):144-147. (In Russ.)

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ISSN 1680-4422 (Print)
ISSN 2618-9801 (Online)