Constitutional characteristics and current chronic glomerulonephritis

Abstract

We observed 38 patients to establish the possible influence of constitutional features (CF) on the course of progressing chronic glomerulonephritis (GN). The protocol of clinical test consisted in detailed anamnesis; physical examination with the account of constitutional features of patients; laboratory and instrumental tests. We compared clinical features of GN, degree of kidney injury, the response to therapy and manifistation of dyscrasic (DD), neuroarthritic (ND) and psoric diathesis (PD). CF involves two components: hereditary on three leading diatheses (DD1, ND1, PD1) and signes of diathesis during patient’s life up to the moment of examination (DD2, AD2, PD2). The analysis of individual variants of GN revealed that disease proceeds more favorably if reaction ability of psoric type was preserved and prevailed. We observed that chronic renal failure in GN patients occurred more lately if the reaction ability of neuroarthritic type was preserved. However, a prevalence of dyscrasic reactions increased the insufficiency of organ function, despite of active therapy.