Renal cancer on the basement of acquired cystic disease of the kidney (ACDK) in nephrologic patients with chronic renal failure (CRF)
Abstract
The development of malignant tumor of the kidney in patients with ACDK may be considered as a combination of urologic and nephrologic problems. We present a review of the literature together with 2 own observations in patients, in whom renal cancer has been developed as a progression of ACDK (0,3% from 681 patients treated in Department of Hemodialysis for 30 years). A man aged 35 with chronic glomerulonephritis at the end stage of renal failure. US examination revealed cystic kidney disease. There was no manifestations of cystic transformation of the other organs as well as no indications on congenital polycystic disease in this patient and his relatives. Cancer of the left kidney up to 3 cm. of inner diameter of the cyst was revealed in autopsy. In other cysts trabecular adenomas were found. This case evidences the difficulties in revealing of this form of renal cancer and its predisposition for multifocal growth. The second case was a man aged 42, with the same diagnosis - cancer of left kidney 7 × 5,5 × 4 cm combined with ACDK was revealed by US examination. Nephrectomy was performed. Macroscopical examination showed multiple small cysts outside the tumor and neoplastic masses in venous lumen. This case demonstrates the possibility of rapid growth and large volumes of tumors and intravenous invasion of renal cancer in patients with ACDK. Peculiarities of the treatment modalities in renal cancer relative to ACDK and hemodialysis are emphasized.
About the Authors
Yu. G. Alyaev
Урологическая клиника и клиника нефрологии, внутренних и профессиональных заболеваний ММА им. И.М. Сеченова, г. Москва
Russian Federation
Russian Federation
N. A. Mukhin
Урологическая клиника и клиника нефрологии, внутренних и профессиональных заболеваний ММА им. И.М. Сеченова, г. Москва
Russian Federation
Russian Federation
D. V. Kochetkov
Урологическая клиника и клиника нефрологии, внутренних и профессиональных заболеваний ММА им. И.М. Сеченова, г. Москва
Russian Federation
Russian Federation
References
1. Аляев Ю.Г., Крапивин А.А. Резекция почки при раке. М.: Медицина, 2001.
2. Антонов А.А., Влодовский Е.А., Гусак И.Я. Ошибки и трудности клинической диагностики рака почки. Врачебное дело 1989; 7: 19-21.
3. Ермоленко В.М. Злокачественные новообразования у больных уремией. Урол. и нефрол. 1987; 4: 67-70.
4. Ермоленко В.М., Балкарова О.В., Коган Е.А. О злокачественных новообразованиях у больных, находящихся на программном гемодиализе. Клин. мед. 1987; 65; 8: 115-117.
5. Ермоленко В.М. Хроническая почечная недостаточность. Нефрология: Руководство для врачей. М.: Медицина, 2000: 641-642.
6. Николаев А.Ю., Милованов Ю.С. Лечение почечной недостаточности: Руководство для врачей. М.: ООО «Медицинское информационное агентство», 1999.
7. Рябов С.И. Нефрология: Руководство для врачей. СПб.: СпецЛит, 2000.
8. Bommer J., Waldherr R., Ritz E. Kidney lesions in uremic patients and β2-microglobulin derived amyloid. Lancet 1985; 2: 1437-1438.
9. Bush A., Gabriel R. Clin. Nephrol. 1984; 22: 77-81.
10. Dunnill M., Millard P., Oliver D. J. clin. Path. 1977; 30: 868-877.
11. Elliott H., McDougall A., Buchanan W. Lancet 1977; 11: 1359.
12. Feiner H., Katz L., Gallo G. Lab. Invest. 1979; 40: 253-254.
13. Feiner H.D., Katz L.A., Gallo G.R. Acquired cystic disease of kidney in chronic dialysis patients. Urology 1981; 17 (3): 260-264.
14. Fujita K. A study of the native kidneys in patients with chronic renal failure. Report 1: Morphological changes and occurrence of acquired cysts of the native kidneys in patients with chronic renal failure. Nippon Hinyokika Gakkai Zasshi 1990; 81 (8): 1140-1147.
15. Fujita K. A study of the native kidneys in patients with chronic renal failure. Report 2: Correlation between cystic changes in native kidneys and development of renal tumor. Nippon Hinyokika Gakkai Zasshi 1990; 81 (8): 1148-1154.
16. Hatano T., Koyama Y., Hayakawa M., Ogawa Y., Osawa A. Evidence for association between renal cell carcinomas and renal cystic diseases: nationwide survey in Japan. Nippon Hinyokika Gakkai Zasshi 1996; 87 (12): 1297-1304.
17. Hatano T., Koyama Y., Hayakawa M., Ogawa Y., Osawa A. Prognosis of renal cell carcinoma coexisting with renal cystic diseases-results of nationwide survey in Japan. Nippon Hinyokika Gakkai Zasshi 1997; 88 (6): 624-631.
18. Herr H., Engen D., Hostetler J. J. Urol. (Baltimore) 1979; 121: 584-586
19. Ikeda D., Tokunaga S., Rahman M., Ohkawa M., Urayama H. A case of renal cell carcinoma extending into the inferior vena cava in a long-term hemodialysis patient. Hinyokika Kiyo. 1995; 41 (6): 461-465.
20. Ikeda R., Suzuki K., Tsugawa R. Renal cell carcinoma and acquired cystic disease of the kidneys in patients on long-term hemodialysis. Hinyokika Kiyo. 1995; 41 (9): 709-717.
21. Ishikawa I., Saito Y., Onouchi Z. et al. Clin. Nephrol. 1980; 14: 1-6.
22. Ishikawa I., Onouchi Z., Yasuhito Saito et al. Sex difference in acquired cystic disease of the kidney on long-term dialysis. Nephron. 1985; 39: 336-340.
23. Ishikawa I. Adenocarcinoma of the kidney in chronic hemodialysis patients in Japan - Nationwide questionnaire and review of case reports. Jap. J. Nephrol. 1986; 28: 1299-1303.
24. Jacobs C., Brunner F., Brynger H. et al. Transplant. Proc. 1981; 13: 729-732.
25. Kantor A., Hoover R., Kinlen L. et al. Cancer in patients receiving long-term dialysis treatment. Amer. J. Epidem. 1983; 118: 437-438.
26. Katz A., Sombolos K., Oreopoulos D. Acquired cystic disease of the kidney in association with chronic ambulatory peritoneal dialysis. Amer. J. Kidney Disease. 1987; 9: 426-429.
27. Kawamura K., Ikeda R., Suzuki K. Acquired renal cystic disease. Hinyokika Kiyo. 2000; 46 (9): 651-656.
28. Linder A., Farewell W., Sherrard D. Ibid. 1981; 27: 292-296.
29. MacDougall M., Wiegmann T. Amer. J. Kidney Dis. 1984; 4: 11-15
30. Miach P., Dawborn J., Xipell. Clin. Nephrol. 1976; 5: 101-104.
31. Mickisch O., Bommer J., Bachmann S. et al. Multicystic transformation of kidney in chronic renal failure. Nephron. 1984; 38: 93-99.
32. Narasimhan N., Wolfson M., Golper T. et al. Comparative diagnostic accuracy of computerized tomography (CT) and gray scale ultrasonography (US) in acquired renal cystic disease. Kidney int. 1985; 27: 147.
33. Nishikawa Z., Kataoka A., Yuasa T. et al. Renal cell carcinoma in acquired cystic disease of the kidney manifested by spontaneous renal hemorrhage. Nippon Hinyokika Gakkai Zasshi 2000; 91 (12): 727-730.
34. Ratcliffe P., Dunnill M., Oliver D. Brit. med. J. 1983; 287: 1855-1858.
35. Sasagawa I., Terasawa Y., Ishizaki M. et al. Comparison of ultrasonography, computerized tomography and angiography in dialysis patients with renal cell carcinoma. Urol. Int. 1992; 49 (4): 206-210.
36. Satoh T., Nagata M., Nukui F., Kurokawa J., Okamoto S., Fukui J., Ohiwa T. A case of renal oncocytoma associated with acquired cystic disease of the kidney. Hinyokika Kiyo. 1998; 44 (7): 493-496.
37. Talamo T., Shonnard J. J. Urol. (Baltimore) 1980; 124: 132-134.
38. Terasawa Y., Fukuda Y., Suzuki Y. et al. Ultrasonic diagnosis of renal cell carcinoma in hemodialysis patients. Nippon Hinyokika Gakkai Zasshi. 1993; 84 (12): 2137-2145.
39. Turani H., Levi J., Zevin D., Kessler E. Israel J. med. Sci. 1983; 19: 614-618.
40. Vaziri N., Darwish R., Martin D., Hostetler J. Nephron. 1984; 37: 203-205.
Review
For citations:
Alyaev Yu.G., Mukhin N.A., Kochetkov D.V. Renal cancer on the basement of acquired cystic disease of the kidney (ACDK) in nephrologic patients with chronic renal failure (CRF). Nephrology and Dialysis. 2002;4(2):121-125. (In Russ.)
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