Anemia and left ventricular diastolic function in pre-dialysis patients
Abstract
52 non-diabetic pre-dialysis patients (28 females, 24 males, mean age 47 ± 12 years) were studied. Serum creatinine was 275,6 ± 176,2 µmol/l, hemoglobin - 116,3 ± 21,5 (range 73-160) g/l. M-mode and Doppler echocardiography was performed. Left ventricular hypertrophy was detected in 43 (82,7%) patients. Early and atrial peak filling velocities ratio (E/A) was decreased in 20 (38,5%), and isovolumic relaxation time of left ventricular was increased in 38 (73,1%) patients. Negative correlation between hemoglobin concentration and early peak filling velocity was revealed (r = -0,50; p < 0,001). The correlation was not detected between hemoglobin concentration and atrial peak filling velocity. We conclude that anemia impact on transmitral flow in pre-dialysis patients. Anemia increase the speed of early filling of the left ventricular. An atrial filling velocity is not change. In this connection the E/A ratio is not reflect the real degree of diastolic dysfunction in patients with chronic renal failure and anemia.
About the Authors
A. M. Shutov
Кафедра госпитальной терапии Ульяновского государственного университета и центральная городская клиническая больница
Russian Federation
Russian Federation
E. S. Kulikova
Кафедра госпитальной терапии Ульяновского государственного университета и центральная городская клиническая больница
Russian Federation
Russian Federation
T. N. Ivashkina
Кафедра госпитальной терапии Ульяновского государственного университета и центральная городская клиническая больница
Russian Federation
Russian Federation
N. I. Kondratyeva
Кафедра госпитальной терапии Ульяновского государственного университета и центральная городская клиническая больница
Russian Federation
Russian Federation
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Review
For citations:
Shutov A.M., Kulikova E.S., Ivashkina T.N., Kondratyeva N.I. Anemia and left ventricular diastolic function in pre-dialysis patients. Nephrology and Dialysis. 2001;3(4):422-426. (In Russ.)
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