Experimental models of acute renal injury

A variety of experimental animal models which mimic renal failure of different origin have been used to study the pathogenic mechanisms of acute kidney injury (AKI) and to test nephroprotective strategies. Detailed description of existing animal models of AKI helps to understand the specific methodology of each experiment and to interpret the obtained results correctly. Glycerol-induced kidney injury in animals closely mimics the rhabdomyolysis. Use of such drugs as gentamicin, cisplatin, ifosfamide, diclofenac stimulates AKI and mimics renal failure due to clinical administration of respective drugs. Animal model of radiocontrast-induced AKI mimics renal failure caused by radiocontrast media during angiography. Experimental model of uranium, potassium dichromate-induced AKI simulates the occupational hazard. Using of S-(1,2-dichlorovinyl)-L-cysteine, ferric nitriloacetate-induced AKI imitates contaminated water-induced renal dysfunction. Animal model of sepsis-induced AKI mimics the infection-induced renal failure. A variety of experimental models ischemia-reperfusion (I/R)-induced AKI simulate the hemodynamic changes specific to decreasing renal blood flow. A detailed model of I/R AKI by bilateral clamping of renal pedicles in rats with specification of technical issues, different variants of experiment, their peculiarities and difficulties is also described.

острое почечное повреждение, лабораторные животные, эксперимент, глицерин, гентамицин, цисплатин, диклофенак, сепсис, уран, ишемически-реперфузионное повреждение, acute kidney injury, laboratory animals, experiment, glycerol, gentamicin, cisplatin, diclofenac, sepsis, uranium, ischemia-reperfusion injury

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