Nontraditional method of correction of protein-energy malnutrition in patients on hemodialysis

Abstract

The aim of the study. To evaluate the relationship between colonization of the gastric mucosa with Helicobacter pylori and protein-energy deficiency (PED) in patients receiving chronic hemodialysis. Patients and methods. 102 patients with end-stage renal disease receiving chronic hemodialysis, among which were 52 men and 50 women aged 49±7.7 years. All patients underwent endoscopy with biopsy of antrum and body of the stomach and the determination of infection with Helicobacter pylori. The nutritional status and composition of the patient's body components were estimated using the method of comprehensive nutritional evaluation, caliperometry, bioimpedance analysis body composition. Determining the level of acyl-ghrelin serum was performed using enzyme-linked immunosorbent assay (ELISA) using commercial kits (Spi-bio, Montignyle Bretonneux, France). Results. In the course of the study the deterioration of some key indicators of nutritional status based on the presence of Helicobacter pylori (HP) was demonstrated. The level of acyl-ghrelin serum in patients with HP colonization was reduced. After the 14 days of eradication therapy of HP we saw improvements in key nutrition indicators and increase the concentration of acyl-ghrelin. Conclusions. Eradication therapy Helicobacter pylori can be considered as an additional method of PEW correction in Hp-positive hemodialysis patients.