IL-10, IL-8 in Serum of Children with Different Variants of Steroid-Sensitive Nephrotic Syndrome of Primary Chronic Glomerulonephritis

Abstract

Experimental data concerning cytokine production dysfunction associated with nephrotic syndrome with minimal change are highly controversial. The insufficiency of interleikyne-10 (IL-10) which suppresses vascular permeability factor and many other anti-inflammatory cytokines secretion play an important role in the development of this condition. Data on disbalanced production of IL-10 in clinic are particularly insufficient. We conducted the direct measurements and analyzed IL-10 and IL-8 blood level in 7 children with steroid-sensitive nephrotic syndrome. The patient in the acute phase of the disease had the decreased down to 0.8 pg/ml IL-10 level. It increased up to 5 pg/ml (6 times) at the beginning of remission. IL-8 was not found in any patient with the remission period of steroid-sensitive nephrotic syndrome, IL-10 in 4 patients was higher normal. Thus the increased IL-10 production at the beginning of remission with its consequent normalization contributes to the elimination of T-lymphocytes dysfunction, IL-8 inhibition and promotes the active phase- remission period transition of the steroid-sensitive nephrotic syndrome.