The Pathogenetic Role Of Platelet Nitric Oxide In Children With Nephropathy
Abstract
In order to investigate the role of NO in pathogenesis of nephropathy in children we examined 29 patients (from 4 to 14 year old) with different kidney diseases and normal renal function. In all of them NO platelet synthesis was measured by spectrofotometric determination of its stable metabolites (NO2-+NO3-). The investigation confirms the important role of NO in pathogenesis of kidney dieases. The increased NO platelet synthesis in children with nephropathy is associated with high activity of inflammation in renal tissue. The difference between patients with pyelonephritis and glomerulonephritis may be a reflection of different inflammatory mechanisms of these diseases.
About the Authors
S. S. Paunova
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
A. G. Kycherenko
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
Ch. M. Marcov
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
L. A. Revenkova
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
N. L. Goltsova
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
E. A. Temerina
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
O. V. Anokhina
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
V. I. Komar
НЦЗД РАМН, РГМУ, Москва
Russian Federation
Russian Federation
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Review
For citations:
Paunova S.S., Kycherenko A.G., Marcov Ch.M., Revenkova L.A., Goltsova N.L., Temerina E.A., Anokhina O.V., Komar V.I. The Pathogenetic Role Of Platelet Nitric Oxide In Children With Nephropathy. Nephrology and Dialysis. 2000;2(1-2):48-51. (In Russ.)
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