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Contemporary review of contrast-induced acute kidney injury. An interventional radiologist notion

https://doi.org/10.28996/1680-4422-2017-3-407-417

Abstract

Clinically relevant contrast-induced acute kidney injury (CI-AKI) is a severe complication of interventional contrast-based procedures of all kinds. It is linked to high morbidity, mortality, social and financial losses. Acute renal damage after coronary angiography or percutaneous coronary intervention may occur in 1-2% cases in general population or in more than 50% of cases with high risk of developing CI-AKI. It is very important to identify existing compromised renal function in a high-risk patient, as it is a major and frequent CI-AKI predisposing factor. There are novel biomarkers with rapid or nearly instant response to acute subclinical contrast-induced renal damage, which are highly valuable in CI-AKI diagnosis and for this reason desire deeper clinical research. Despite a number of controversies, prophylactic and therapeutic measures are practically the same in a vast majority of guidelines. Intravenous 0.9% NaCl solution remains one and only proved measure in CI-AKI prophylaxis and therapy, while the use of other pharmacological approaches still needs more relevant prospective clinical research. The aim of this paper was review contemporary, CI-AKI-devoted, evidence-based data.

About the Authors

A. A. Khilchuk
City Hospital №40
Russian Federation


S. V. Vlasenko
City Hospital №40; Saint-Petersburg State University
Russian Federation


S. G. Scherbak
Saint-Petersburg State University
Russian Federation


A. M. Sarana
Saint-Petersburg State University
Russian Federation


A. M. Babunashvili
Center for Endoscopic surgery and Lithotripsy
Russian Federation


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Khilchuk A.A., Vlasenko S.V., Scherbak S.G., Sarana A.M., Babunashvili A.M. Contemporary review of contrast-induced acute kidney injury. An interventional radiologist notion. Nephrology and Dialysis. 2017;19(3):407-417. (In Russ.) https://doi.org/10.28996/1680-4422-2017-3-407-417

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