Drug-induced acute kidney injury in patients with chronic kidney disease
Abstract
Recent epidemiological and clinical studies suggest that drug-induced acute and chronic kidney diseases are closely connected. Multiple risk factors for acute kidney injury are AKI (prerenal kidney injury, postrenal urinary tract obstruction, and intrinsic renal diseases) including advanced age, diabetes mellitus, hypertension and afro-american race. However, the most important risk factor for acute kidney injury is preexisting chronic kidney disease, which increases the risk of AKI in 10 folds compared to case of the absence of chronic kidney disease. AKI increases the risk of progression CKD to terminal uremia аnd may lead to chronic kidney disease regardless the cause of the acute injury. The prognostic importance of a small acute decrement in kidney function is discovered. Association between the acute tubular necrosis and long-term renal and cardiovascular outcomes is discussed. Both AKI and CKD are the risk factors for cardiovascular disease.
About the Authors
A. Yu. Nikolaev
Russian Medical Academy of postgraduate education, Russiаn Ministry of health
Russian Federation
Russian Federation
V. M. Ermolenko
Russian Medical Academy of postgraduate education, Russiаn Ministry of health
Russian Federation
Russian Federation
References
1. Ермоленко В.М., Николаев А.Ю. Острая почечная недостаточность. М.: «ГЭОТАР-Медиа», 2010. 236 с.
2. Николаев А.Ю., Ермоленко В.М. Место блокаторов РАС в нефропротективной стратегии при хронической болезни почек. Нефрология и диализ. 2010. 12(1): 8-12.
3. Аlcazar S.L., Hunt B., Gomez-Campdera F. Clinical characteristics of ischemic renal disease. Nephrol. Dial. Transplant. 2001. 16 [suppl.1]: 74-77.
4. Alves S.C., Tomasi C.D., Constantino L. Hypomagnesemia as a risk factor for non-recovery of the renal function in critically ill patients with acute kidney injury. Nephrol. Dial. Transplant. 2013. 28(4): 910-916.
5. Anderson S., Eldadah B. AKI in older adults. J. Am. Soc. Nephrol. 2011. 22(22): 28-38.
6. Besbas N., Karpman D., Landau D. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. Kidney Int. 2006. 70 (3): 423-431.
7. Chawla L.S., Eggers P., Star R.A. AKI and CKD: an integrated clinical syndromes. N. Engl. J. Med. 2012. 82(5): 516-524.
8. Chawla L.S., Amdur P.L. The association between AKI and long-term renal and cardiovascular outcomes in US veterans. Clin. J. Am. Soc. Nephrol. 2014. 9(9): 448-456.
9. Clermont G., Asker C.G. Angus D. Renal failure in the ICU. Kidney Int. 2002. 62(3): 986-996.
10. Coca S.G, Peixoto A.J., Garg A.X. The prognostic importance of a small acute decrement of kidney function in hospitalized patients: a systematic review and meta-analysis.
11. Am. J. Kidney Dis. 2007. 50(5): 712-720.
12. Coca S.G., Singanamala P., Parik S. CKD after AKI
13. a systematic review and meta-analysis. Kidney Int. 2012. 81(5): 442-448.
14. Decaux G. V2-antagonists for the treatment of hyponatraemia. Nephrol. Dial. Transplant. 2007. 22(7): 1853-1855.
15. Gaffo A.L., Saag K.G. Management of hyperuricemia and Gout in CKD. Am. J. Kidney Dis. 2008. 52(5): 994-1009.
16. Gines P., Torre A., Terra C. Pharmacological treatment of hepatorenal syndrome. Aliment. Pharmacolol. Ther. 2004. 20 [Suppl.3]: 57-62.
17. Ischani A., Himmelfarb O., Xue J.L. AKI increases risk of ERSD among elderly. J. Am. Soc. Nephrol. 2006. 20(1): 223-228.
18. Izzedine H., Baumelou A., Deray G. Acute renal failure in HIV patients. Nephrol. Dial. Transplant. 2007. 22(10): 2757-2762.
19. James M.T., Chali W.A. Association between AKI and cardiovascular and renal outcomes after coronary angiography. Circulation. 2011. 123(4): 409-416.
20. Kanbay M, Yilmaz M.I. Relationship between serum magnesium levels and cardiovascular events in CKD patients. Am. J. Nephrol. 2012. 36(3): 228-237.
21. Karumanchi S.A., Epstein F.H. Placental ischemia and soluble fms-like tyrosine kinase-1 (sFlt-1): a cause or consequence of preeclampsia. Kidney Int. 2007. 71(10): 959-961.
22. Kielstein J.T. David S. Magnesium: the earth cure of AKI? Nephrol. Dial. Transplant. 2013. 28(4): 785-787.
23. Levey A.S., Coresh J. Chronic Kidney Disease. Lancet. 2012. 379(9811): 165-180.
24. Muriithi A.K., Leung N., Valeri A. Biopsy-proven acute interstitial nephritis, 1993 - 2011. A case series (Mayo Clinic). Am. J. Kidney Dis. 2014. 64 (4): 558-566.
25. Nair R., Bell J.M., Walker P.P. Renal biopsy in patients aged 80 years and older. Am. J. Kidney Dis. 2004. 44(4): 618-626.
26. Nash K., Hafeez A., Hou S. Hospital-acquired renal insufficiency. Am. J. Kidney Dis. 2002. 39(5): 930-936.
27. Onuigbo M.A., Onuigbo N.T. Late-onset renal failure from angiotensin blockade (LORFFAB) in 100 CKD patients. Int. Urol. Nephrol. 2008. 40(1): 233-239.
28. Palevsky P. Chronic-on-acute kidney insufficiency. Kidney Int. 2012. 81(5): 430-431.
29. Palmer B.F. Renal dysfunction complicating the treatment of hypertension. N. Engl. J. Med. 2002. 347(16): 1256-1261.
30. Radhakrishnan J., Kirglu. K. Acute renal failure outcomes in children and adults. Kidney Int. 2006. 69(1): 17-19.
31. Ronco C., Bellomo R., McCullough P. Cardiorenal syndrome in critical care unit. Contrib. Nephrol. Basel. Karger, 2010. 165: 456 р.
32. Ronco C., McCullough P., Ankor S. Cardiorenal syndromes: report from the consensus conference of the Acute Dialysis Quality Initiative. ur. Heart J. 2010. 31(6): 703-711.
33. Said S.M., Nasr S.H. Nephrotoxicity of antiretroviral therapy in HIV-infected patients. Kidney Int. 2007. 71(10): 1071-1075.
34. Sam A.D., Morasch M.D., Collins J. Safety of gadolinium contrast angiography. J. Vasc. Surg. 2003. 38(3): 313-318.
35. Schiffle H. Renal recovery from acute tubular necrosis, requiring renal replacement therapy: a prospective study in critically ill patients. Nephrol. Dial.Transplant. 2006. 21(5): 1248-1252.
36. Schrier R.W., Sharma S., Щекочихин Д.Ю. Hyponatraemia: more than just a marker of disease severity? Nature Reviews Nephrol. 2013. 9(1): 37-50.
37. Thakar C.V., Jared J-P., Wordley S. Renal disfunction, a serious infections after open-heart surgery. Kidney Int. 2003. 64(1): 239-246.
38. Theriault J., Agharazzi M., Dumont M. Atheroembolic renal failure requiring dialysis: potential for renal recovery. Nephrol. Clin. Pract. 2003. 94(1): 11-18.
39. US Renal Data System USRDS. 2007 annual data report. Bethesda, MD. National Institute of Diabetes, and Digestive and Kidney diseases. Nat. Inst. of Health. 2007.
40. Venkatachalam M.A., Griffin K.A. AKI: a springboard for progression in CKD. Am.J. Physiol. Renal Physiol. 2010. 298(5): 1078-1094.
41. Vlahacos D., Manginas A., Chilidou D. Itraconazole-induced rhabdomyolysis and ARF in a heart transplant recipients treated with simvastastin and cyclosporine. Transplantation. 2002. 73(12): 1962-1964.
42. Wald R., Quinn R.R. Lu J. Chronic dialysis and death among survivors of AKI requiring dialysis. J.A.M.A. 2009. 202(11): 1179-1185.
43. Wang H., Lofgren V. Age-specific and sex-specific mortality in 187 countries 1970- 2010: a systemic analysis. Lancet. 2010. 380(9859): 2071-2094.
44. Woywodt A., Schwartz A. Mengel M. Nephrotoxicity of selective COX-2 inhibitors. J. Rheumatol. 2001. 28(9): 2133-2135.
45. Xue J.L., Daniels F. Incidence mortality of ARF in medicare beneficiares, 1992 -2001. J. Am. Soc. Nephrol. 2006. 17(4): 1135-1142.
Review
For citations:
Nikolaev A.Yu., Ermolenko V.M. Drug-induced acute kidney injury in patients with chronic kidney disease. Nephrology and Dialysis. 2015;17(1):29-33. (In Russ.)
Views:
38
Email this article 