Role of apoptosis in chronic kidney disease progression in childhood
Abstract
Apoptosis contributes significantly to the glomerular and interstitial sclerosis, the morphological basis of the CKD progression. It leads to the imbalance between glomerular and tubular epithelial cell proliferation and loss due to hyperactivity of Fas-mediated apoptosis. The serum activity of apoptosis markers: a soluble Fas-ligand (sFas-L), metalloproteinase-9 (MMP-9) and its tissue inhibitor (TIMP-1) were investigated in children with CKD1–4 stage. A significant excess of the marker’s activity compared to their normal values at all stages of CKD; the prevalence of apoptotic activity in nephrotic proteinuria patients with GFR >90, significant influence of poor prognostic factors complex: proteinuria, hypertension and hypercholesterolemia on the activity of sFas-L, MMP-9, TIMP-1 were discovered. These results give an opportunity to indicate the biological significance of programmed cell death in the development and progression of renal diseases.
Keywords
apoptosis,
chronic kidney disease,
MMP-9,
TIMP,
sFas-L,
apoptosis,
chronic kidney disease,
MMP-9,
TIMP,
sFas-L
About the Authors
O. V. Komarova
«Scientific Centre of Children’s Health» under Russian Academy of Medical Science
Russian Federation
Russian Federation
A. G. Kucherenko
«Scientific Centre of Children’s Health» under Russian Academy of Medical Science
Russian Federation
Russian Federation
I. E. Smirnov
«Scientific Centre of Children’s Health» under Russian Academy of Medical Science
Russian Federation
Russian Federation
A. N. Tsygin
«Scientific Centre of Children’s Health» under Russian Academy of Medical Science
Russian Federation
Russian Federation
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Review
For citations:
Komarova O.V., Kucherenko A.G., Smirnov I.E., Tsygin A.N. Role of apoptosis in chronic kidney disease progression in childhood. Nephrology and Dialysis. 2013;15(2):135-139. (In Russ.)
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