Daily profile of the augmentation index in teenagers after renal transplantation
Abstract
Cardiovascular complications are a principal cause of death in patients with chronic kidney insufficiency. The augmentation index (Aix) is an independent predictor for cardiovascular mortality. The purpose of our research was to study a level and a daily rhythm of Aix in control (healthy teenagers, 10 persons, mean age 14 ± 2 years) and in patients with a functioning kidney transplant (36 persons, mean age 12,88 ± 3,3 years) with 24-hour ambulatory arteriograph BPLab („Petr Telegin“, Nizhny Novgorod, Russia). Transplantation had been performed 3,3 ± 3,2 years prior to examination. Control patients had a significantly lower mean arterial blood pressure (MBP) and mean Aix (MBP 79,17 ± 4,3 mmHg vs . 86,36 ± 9,5 mmHg CI 0,5/13,8, Aix – –55,22 ± 6,4%, –42 ± 18,4% CI 0,4/25, respectively). The plot of the daily profile of Aix in the control group had two peaks (at 11–12 and at 19–20 hours), the maximum values were in the day time, and the minimal values were at night. The daily profile of Aix in patients had the maximum at night. We found no significant correlations between Aix and serum creatinine level, cyctatin C, glomerular filtration rate, dose of immunosuрpressive medications, antihypertensive therapy or MBP. The study suggests that subclinical arteriopathy is often prеsent in young transplant recipients.
About the Authors
S. L. Moiseeva
Universitätsklinikum Eppendorf (UKE), Hamburg
Russian Federation
Russian Federation
E. Müller-Wiefel Prof. Dr. Dirk
Universitätsklinikum Eppendorf (UKE), Hamburg
Russian Federation
Russian Federation
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For citations:
Moiseeva S.L., Prof. Dr. Dirk E.M. Daily profile of the augmentation index in teenagers after renal transplantation. Nephrology and Dialysis. 2010;12(2):097-100. (In Russ.)
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