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Том 10 №1 2008 год - Нефрология и диализ

Фокально-сегментарный гломерулосклероз (Обзор литературы)


Наушабаева А.Е. Канатбаева А.Б. Диканбаева С.А.

Аннотация: Фокально-сегментарный гломерулосклероз (ФСГС) представляет собой целую группу заболеваний с различной этиологией, патогенезом и клиническими проявлениями, среди которых основной - протеинурия [43]. ФСГС является первой причиной нефротического синдрома (НС) у взрослых [32] и первой причиной стероид-резистентного НС (СРНС) у детей. В последние десятилетия отмечается рост частоты ФСГС по всему миру. При ФСГС выявляется поражение подоцитов (II) различной этиологии, в связи с чем болезнь стала рассматриваться как «подоцитопатии».

Для цитирования: Наушабаева А.Е., Канатбаева А.Б., Диканбаева С.А. Фокально-сегментарный гломерулосклероз (Обзор литературы). Нефрология и диализ. 2008. 10(1):6-76. doi:


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Ключевые слова: фокально-сегментарный гломерулосклероз, нефротический синдром, фактор проницаемости, подоциты, белки щелевой диафрагмы, нефрин, подоцин

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