Cystatin C as a marker of renal functions in children with CKD
Abstract
In modern nephrology GFR is usually estimated by serum creatinine level or calcualed with e-formulas. In pediatric nephrology the Schwartz formula is frequently used. Recently cystatin C (CsC) was suggested as an alternative marker for GFR estimation. The aim of our study was to determine the level of cystatin C and to evaluate this marker for the assessment of renal function in children with different stages of chronic kidney diseases (CKD). 105 children with CKD 1–3 st. were examined. In children with CKD 1 st. the average serum CsC levels was 1144,3 ± 170 ng/ml with no significantly different from the comparison group (870 ± 200 ng/ml) and from the reference figure of 940 ± 270 ng/ml reported by G. Filler (1999). In children with steroid-resistant nephrotic syndrome (GFR >90 ml/min) the CsC level was significantly higher than in the control and reference groups 1647 ± 263 ng/ml (p < 0,05). In children in remission stage of steroid-sensitive/steroid-dependent nephrotic syndrome (GFR >90 ml/min) the CsC level did not differ significantly from its values in the comparison groups 988 ± 230 ng/ml. In children with non-glomerular pathology (GFR >90 ml/min) the level of CsC was higher, 1185,7 ± 191 ng/ml. Children with CKD 2 and 3 st. had significantly higher CsC serum level than in the CKD-1 patients, and in control and reference groups (1754 ± 325 и 3171 ± 918 ng/ml, correspondingly). Thus, we found a significant increase in the serum CsC level in children with GFR <90 ml/min. In functionally compensated stages of CKD a significantly higher CsC level was found in patients with poor prognostic variants of CKD. This confirms that cystatin C to be an early marker for GFR estimation.
About the Authors
O. V. Komarova
Scientific center of Children health of the Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
A. N. Tsygin
Scientific center of Children health of the Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
A. G. Kucherenko
Scientific center of Children health of the Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
I. E. Smirnov
Scientific center of Children health of the Russian Academy of Medical Sciences, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Komarova O.V., Tsygin A.N., Kucherenko A.G., Smirnov I.E. Cystatin C as a marker of renal functions in children with CKD. Nephrology and Dialysis. 2010;12(4):271-274. (In Russ.)
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