Сосудистое поражение почек при антифосфолипидном синдроме (Обзор литературы)
Аннотация
Последние десятилетия отмечены возрастающим интересом исследователей к широкому кругу заболеваний, в основе прогрессирования которых лежат механизмы сосудистого повреждения. Он включает в себя атеросклероз, гипертоническую болезнь, сахарный диабет, системные васкулиты. В конце XX в. в этот круг вошел описанный G.R.V. Hughes антифосфолипидный синдром (АФС) - симптомокомплекс, проявляющийся венозными и/или артериальными тромбозами, привычным невынашиванием беременности и тромбоцитопенией, которые сочетаются с гиперпродукцией антител к фосфолипидам (АФЛ) [50, 54, 55]. По современным представлениям последние обуславливают развитие гиперкоагуляционного состояния свертывающей системы крови (аутоиммунной тромбофилии), реализующегося тромбообразованием в сосудах как крупного, так и малого калибра, что может приводить к развитию полиорганной ишемии, а иногда и полиорганной недостаточности
Об авторе
Н. Л. Козловская
Кафедра нефрологии и гемодиализа ФППОВ ММА им. И.М. Сеченова, г. Москва
Россия
Россия
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Рецензия
Для цитирования:
Козловская Н.Л. Сосудистое поражение почек при антифосфолипидном синдроме (Обзор литературы). Нефрология и диализ. 2006;8(3):206-219.
For citation:
Kozlovskaya N.L. Renal vascular lesion in antiphospholipid syndrome Review. Nephrology and Dialysis. 2006;8(3):206-219. (In Russ.)
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