The role of analgetics and non-steroid anti-inflammatory drugs in development of renal interstitial damage
Abstract
The aim of the study was to reveal kidney pathology occurence in patients treated with analgetics (A) and non-steroid anti-inflammatory drugs (NSAID) in different departments of a general hospital, excluding the urological and nephrological ones. At the first stage of the screening, urine analysis (UA) and blood test were taken from the case histories of 1446 patients (690 men, average age 50 years; 756 women, average age 45 years). On the second stage, data concerning A and NSAID (doze, frequency, duration of treatment) were analysed. At the third stage the data were analysed statistically. 649 (44,9%) patients were treated with A or/and NSAID, 797 (control group) did not receive these drugs. A UA-pathology was found in 351 (24,3%) cases. A UA-pathology and a renal function (RF) impairment was significantly higher in patients treated with A or NSAID (and especially with both A and NSAID) than in control group. A positive correlation between UA-pathology, RF-impairment and drug doze was found.
About the Authors
M. M. Batyushin
ГОУ ВПО «Ростовский государственный медицинский университет» Федерального агентства по здравоохранению и социальному развитию, г. Ростов-на-Дону
Russian Federation
Russian Federation
O. V. Dmitrieva
ГОУ ВПО «Ростовский государственный медицинский университет» Федерального агентства по здравоохранению и социальному развитию, г. Ростов-на-Дону
Russian Federation
Russian Federation
V. P. Terentiev
ГОУ ВПО «Ростовский государственный медицинский университет» Федерального агентства по здравоохранению и социальному развитию, г. Ростов-на-Дону
Russian Federation
Russian Federation
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Review
For citations:
Batyushin M.M., Dmitrieva O.V., Terentiev V.P. The role of analgetics and non-steroid anti-inflammatory drugs in development of renal interstitial damage. Nephrology and Dialysis. 2006;8(3):239-243. (In Russ.)
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