Mycophenolate mofetil in treatment of children with glomerulopathies
Abstract
In this study an efficacy of Mycophenolate Mofetil in 20 children (8 with steroid-dependent and steroid-resistant nephrotic syndrome, 5 with chronic glomerulonephritis of nephritic type, 6 with Genoch-Shoenlein nephritis and 1 with lupus-nephritis) was assessed. Treatment with Mycophenolate Mofetil was more efficient in children with steroid-dependent nephrotic syndrome. It was also effective in children with chronic nephritic syndrome and Genoch-Shoenlein nephritis.
About the Authors
A. B. Kanatbayeva
Казахский национальный медицинский университет
Russian Federation
Russian Federation
S. A. Dikanbayeva
Казахский национальный медицинский университет
Russian Federation
Russian Federation
B. A. Abeuova
Казахский национальный медицинский университет
Russian Federation
Russian Federation
P. P. Karabidi
Республиканская детская клиническая больница «Аксай»; г. Алматы, Казахстан
Russian Federation
Russian Federation
A. E. Naushabayeva
Республиканская детская клиническая больница «Аксай»; г. Алматы, Казахстан
Russian Federation
Russian Federation
N. B. Nigmatullina
Казахский национальный медицинский университет
Russian Federation
Russian Federation
N. M. Mustapaeva
Казахский национальный медицинский университет
Russian Federation
Russian Federation
References
1. Allison A.C., Eugui E.M., Sollinger H.W. Mycophenolate mofetil (RS-61443): Mechanism of action and effects in transplantation. Transplant Rev 1993; 61: 129-139.
2. Allison A.C., Eugui E.M. Immunosuppressive and other effects of mycophenolic acid and an ester prodrug, mycophenolate mofetil. Immunol Rev 1993; 136: 1.
3. Bagga A., Hari P., Moudgil A., Jordan S.C. Mycophenolate mofetil and prednisolone therapy in children with steroid dependent nephrotic syndrome. Am J Kidney Dis 2003; 42 (6): 1114-1120.
4. Briggs W.A., Choi M.J., Sheel P.J. Successful mycophenolate mofetil treatment of glomerular disease. Am J Kidney Dis 1998; 31: 213-217.
5. Day C.J., Cockwell P., Lipkin G.W. et al. Mycophenolate mofetil in the treatment of resistant idiopatic nephrotic syndrome. Nephrol Dial Transplant 2002; 17 (11): 2011-2013.
6. Hauser I.A., Renders L., Radeke H. et al. Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosin depletion. Nephrol Dial Transpl 1999; 14: 58-62.
7. Hogg R.J., Fizgibbons L., Bruick J. et al. Multicenter trial of mycophenolate mofetil (MMF) in children with steroid dependent (SD) or frequent relapsing (FR) nephrotic syndrome (NS). Report of the southwest pediatric nephrology study group. Nephrol Dial Transplant 2003; 18; Suppl. 4: 261.
8. Miller G., Zimmerman R. 3rd., Radhakrishan J., Appel G. Use of mycophenolate mofetil in resistant membranous nephropathy. Am J Kidney Dis 2000, Aug; 36 (2): 250-256.
9. Mogyorosi A., Lippman H.R., Feldman G.M. Successful treatment of steroid resistant minimal change disease with mycophenolate mofetil Am J Ntphrol 2002; 22 (5-6): 569-572.
10. Norona B., Valentun M., Gutierrez T., Praga M. Treatment of steroid dependent minimal change - nephrotic syndrome mycophenolate mofetil. Nefrologia 2004; 24 (1): 79-82.
11. Zhao M., Morris V., Holdman G.N. et al. Mycophenolate mofetil in the treatment of resistant nephrotic syndrome. Am J Kidney Dis 2001; 46 (5): 35-39.
Review
For citations:
Kanatbayeva A.B., Dikanbayeva S.A., Abeuova B.A., Karabidi P.P., Naushabayeva A.E., Nigmatullina N.B., Mustapaeva N.M. Mycophenolate mofetil in treatment of children with glomerulopathies. Nephrology and Dialysis. 2006;8(4):355-358. (In Russ.)
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