Immunological aspects of IgA nephropathy review
Abstract
IgA-nephropathy (IgAN) is the most common form of glomerulonephritis. It is characterized by predominant mesangial polymeric IgA1 deposits and with increased plasma IgA1 level. The level of plasma IgA is determined by the rate of IgA production, its uptake by leucocytes and removal by hepatocytes. The catabolism of IgA depends on two factors: IgA receptors and immunochemical nature of the IgA molecules. Serum IgA in IgAN displays a number of unusual physical characteristics. The most important of them is a change in glicosilation. This IgA defect can influence IgA capacity to interact with matrix proteins, IgA receptors on mesangial cells, leucocytes and hepatocytes and with complement. It may play a key role in the pathogenesis of mesangial deposition of IgA1 and subsequent glomerular injury in IgAN.
About the Authors
V. M. Bespalova
Отделение нефрологии 5-й ГКБ
Russian Federation
Russian Federation
Y. A. Sapojhnikova
Кафедра иммунологии МГЭУ им. А.Д. Сахарова, Беларусь, г. Минск
Russian Federation
Russian Federation
M. M. Zafranskaya
Кафедра иммунологии МГЭУ им. А.Д. Сахарова, Беларусь, г. Минск
Russian Federation
Russian Federation
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Review
For citations:
Bespalova V.M., Sapojhnikova Y.A., Zafranskaya M.M. Immunological aspects of IgA nephropathy review. Nephrology and Dialysis. 2005;7(1):32-36. (In Russ.)
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