Comparative assessment of monoand combined perindopril and amlodipin therapy on the remodeling of left ventricular myocardium in hemodialysis patients
Abstract
Seventy-one arterial hypertension (AH) patients on programmed ambulatory hemodialysis were divided into four groups: 16 patients (Group I), receiving perindopril (4-8 mg in hemodialysis day); 16 patients (Group II), receiving amlodipine (5-10 mg/day); 16 patients (Group III), receiving a combination of perindopril and amlodipine and 21 patients, mostly with Stage I AH (Group IV, controls). Echocardiography, performed 6 months later, demonstrated that perindopril alone and in combination with amlodipine decreased left ventricular myocardial mass, left ventricular myocardial mass index, improved diastolic myocardial function and decreased corrected QTc-interval. Amlodipine as monotherapy prevented progression of ventricular hypertrophy. Combination of perindopril and amlodipine decreased QT and QTc by 12,1 and 7,2%, respectively. Progression of negative dynamics in myocardial structure was observed in patients not receiving antihypertensive therapy.
About the Authors
T. A. Kozlova
Российская медицинская академия последипломного образования
Russian Federation
Russian Federation
V. V. Safonov
Московская медицинская академия им. И.М. Сеченова, г. Москва
Russian Federation
Russian Federation
E. V. Shutov
Российская медицинская академия последипломного образования
Russian Federation
Russian Federation
V. M. Ermolenko
Российская медицинская академия последипломного образования
Russian Federation
Russian Federation
A. V. Kuchtevich
Московская медицинская академия им. И.М. Сеченова, г. Москва
Russian Federation
Russian Federation
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Review
For citations:
Kozlova T.A., Safonov V.V., Shutov E.V., Ermolenko V.M., Kuchtevich A.V. Comparative assessment of monoand combined perindopril and amlodipin therapy on the remodeling of left ventricular myocardium in hemodialysis patients. Nephrology and Dialysis. 2005;7(2):145-149. (In Russ.)
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