A case of a non-hodgkin’s lymphoma manifested by renal failure

Non-Hodgkin’s lymphomas are the group of diseases with different clinical and morphological manifestations related to malignant neoplasms of lymphoid and hematopoietic tissues. Manifestations of non-Hodgkin’s lymphomas depend on the localization of the tumor focus and the tumor cell’s proliferation speed. Initial development of tumor foci in the lymphoid tissue of non-lymphoid organs (gastrointestinal tract, respiratory system, skin, kidney, etc.) is defined as extranodal embodiment of non-Hodgkin’s lymphoma. The clinic manifestations can be caused by dysfunction, compression of the affected organ and neurovascular bundles, as well as by a number of non-specific symptoms associated with tumor progression. Such a wide range of clinical manifestations often makes the diagnosis rather difficult. The kidneys’ defeat in non-Hodgkin’s lymphoma is extremely rare, as the lymphoid tissue in the kidneys is virtually nonexistent. In case of non-Hodgkin’s lymphoma some forms of glomerulonephritis and acute renal failure due to renal parenchymal infiltration of tumor cells or tumor obstruction of the urinary tract and kidneys’ blood vessels can develop. This non-Hodgkin’s lymphoma with primary extranodal localization in the kidneys could make his debut with acute renal failure, and specific symptoms may appear later. In this situation, the difficulties of the hematological diagnosis are entrusted to nephrologists. In this article, we describe a clinical case of non-Hodgkin’s lymphoma, manifested by renal failure due to bilateral renal lymphomatous infiltration.

неходжкинская лимфома, почечная недостаточность, интерстициальный нефрит, экстранодальная лимфома, лимфоматозная инфильтрация почек, non-Hodgkin’s lymphomas, renal failure, interstitial nephritis, extranodal lymphoma, renal lymphomatous infiltration

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