The case of Kaposi`s sarcoma in family members with Alport syndrome after renal transplantation. Case report
Abstract
Alport syndrome is a rare genetic disease characterized by progressive CKD and abnormalities of the hearing and vision. It is also known, that Kaposi’s sarcoma is one of the most common neoplasia in patients after kidney transplantation. The use of immunosuppressant drugs, genetic predisposition and viral infection (human herpesvirus-8) is also associated with post-transplant malignancy. We report a case of simultaneous occurrence and treatment of Kaposi's sarcoma in mother and son with Alport syndrome in the early post-transplant period. Chemotherapy with doxorubicin and conversion to everolimus was used. Our patients have been followed up for two years without any recurrence and with well functioning graft. Everolimus is an immunosuppressive agents, it is an inhibitor of the mammalian target of rapamycin (mTOR) that have specific antiproliferative effects. This observation reflects current interest in the role of mTOR inhibitors in the management of post-transplant tumors - Kaposi's sarcoma.
About the Authors
M. I. Krylova
Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
E. N. Unarova
National center of medicine
Russian Federation
Russian Federation
A. V. Nikolaev
National center of medicine
Russian Federation
Russian Federation
S. P. Shestakova
National center of medicine
Russian Federation
Russian Federation
J. G. Nikolaeva
National center of medicine
Russian Federation
Russian Federation
U. S. Portnyagina
Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
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Review
For citations:
Krylova M.I., Unarova E.N., Nikolaev A.V., Shestakova S.P., Nikolaeva J.G., Portnyagina U.S. The case of Kaposi`s sarcoma in family members with Alport syndrome after renal transplantation. Case report. Nephrology and Dialysis. 2016;18(4):452-458. (In Russ.)
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