New markers of kidney injury in children with obesity
https://doi.org/10.28996/2618-9801-2021-4-499-507
Abstract
Currently, overweight and obesity, in various subjects including children, are the most serious problems in many countries of the world. Kidney injury in patients with obesity is developed imperceptibly, without clinical symptoms. Known markers of kidney disease, associated with obesity are increased serum creatinine, albuminuria, proteinuria, arterial hypertension appearing in the late stages of the disease. The aim of our study was the comparative analysis of urinary markers of renal injury (KIM-1, NGAL, IL-18, β2-m) in obese children and healthy ones (control group). Materials and methods. The study included 84 children aged from 4 to 17 years: 34 obese patients and 50 children of the control group. All children were examined for urinary markers of kidney injury: KIM-1, NGAL, IL-18, and β2-m; the data of the two groups of patients were compared. Results. Statistically significant differences were found of three from the four studied indicators in obese children and in children of the control group: NGAL, KIM-1 and IL-18; in the group of obese children these urinary markers had higher values than in the control group. The concentration of β2-m in urine was similar in both groups of children. When analyzing the normalized data, the results turned out to be the same: statistically significant differences were found for NGAL/Cru (ng/mg), KIM-1/Cru (pg/mg), and IL-18/Cru (pg/mg). Conclusion. It seems to us rational to use such urinary markers as NGAL, KIM-1, IL-18 for detecting early kidney injury in children with exogenous constitutional obesity.
About the Authors
T. L. Nastausheva
N.N. Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
T. V. Chubarov
Voronezh Children’s Hospital
Russian Federation
Russian Federation
A. V. Khan
N.N. Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
E. N. Kulakova
N.N. Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
G. G. Volosovets
N.N. Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
E. M. Chichuga
N.N. Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
A. O. Nikolaev
N.N. Burdenko Voronezh State Medical University
Russian Federation
Russian Federation
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For citations:
Nastausheva T.L., Chubarov T.V., Khan A.V., Kulakova E.N., Volosovets G.G., Chichuga E.M., Nikolaev A.O. New markers of kidney injury in children with obesity. Nephrology and Dialysis. 2021;23(4):499-507. (In Russ.) https://doi.org/10.28996/2618-9801-2021-4-499-507
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