Using of mesenchymal stem cells reduces the level of ischemia-reperfusion injury of various organs in experiments: focus on paracrine mechanisms

Today, conditions such as acute myocardial infarction, ischemic stroke, shock organ injury are the leading causes of death in the world. All these states are accompanied by a syndrome of ischemia-reperfusion injury - paradoxical process when cells damage in the ischemic organ is continued after blood flow recovery. Pathogenesis of ischemia-reperfusion injury is very complex and involves a combination of processes such as inflammation, metabolic imbalance, oxidative stress, etc. The existing treatment of these conditions is insufficient. Therefore, there is a reason to look for alternative approaches for the treatment of ischemia-reperfusion injury. Many studies have demonstrated the effect of mesenchymal stem cells in the ischemia-reperfusion injury of different organs. It seems that their special role in this effect is caused by paracrine factors. In this review, we discuss a number of studies in this field, and try to identify the major pathogenic point of application of mesenchymal stem cells in ischemia- reperfusion injury.

ишемически-реперфузионное повреждение, мезенхимальные стволовые клетки, цитокины, воспаление, факторы роста, ischemia-reperfusion injury, mesenchymal stem cells, cytokines, inflammation, growth factors

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