Kidney function and blood supply in children with inherited thrombophilia
Abstract
The purpose of the study was to determine kidney function and blood supply in children with inherited thrombophilia. Methods: Laboratory tests were performed in 66 children with identified inherited thrombophilia, 22 of them have arterial or venous thrombosis, 44 did not had symptoms, however had strong family history of thromboembolism. The laboratory tests were performed by clinical analysis of blood and urine, biochemistry blood analysis with detection serum level of lipoprotein (a) and homocysteine, blood coagulation tests with activity levels of antithrombin, proteins C and S and antiphospholipid antibody syndrome. 24 h-urine test was also performed. The ultrasound examination with Doppler test was taken in all patients. None of patients had reduced renal function. In 7 (10,6%) children with inherited thrombophilia renal infarction was detected using ultrasound examination. The sonographic sign was hyperechogenic avascular wedge shape zone. All these patients have statistically significant difference in the presence of erythrocyturia, microalbuminuria, nicturia, malfunction of acidoammoniogenesis, enzymuria in comparison with patients with inherited thrombophilia, but without signs of renal infarction. The increased blood level of lipoprotein (a) by more than 2 times is related to kidneys damage in patients with inherited trombophilia that corresponds to increased risk by a factor of 300 or higher. We developed an algorithm to estimate the risk of renal vessel thrombosis in children with inherited thrombophilia depending on blood level of lipoprotein (a) and activity of natural inhibitors of coagulation.
About the Authors
O. L. Chugunova
N.I. Pirogov Russian Medical Research University, Faculty of Pediatry, Department of hospital pediatry I.I. Sechenov Moscow State Medical University, Faculty of postgraduate education, Department of Nephrology and Hemodialysis N.F. Filatov Children city hospital No 13, Moscow
Russian Federation
Russian Federation
M. V. Shumikhina
N.I. Pirogov Russian Medical Research University, Faculty of Pediatry, Department of hospital pediatry I.I. Sechenov Moscow State Medical University, Faculty of postgraduate education, Department of Nephrology and Hemodialysis N.F. Filatov Children city hospital No 13, Moscow
Russian Federation
Russian Federation
N. L. Kozlovskaya
N.I. Pirogov Russian Medical Research University, Faculty of Pediatry, Department of hospital pediatry I.I. Sechenov Moscow State Medical University, Faculty of postgraduate education, Department of Nephrology and Hemodialysis N.F. Filatov Children city hospital No 13, Moscow
Russian Federation
Russian Federation
A. I. Gurevich
N.I. Pirogov Russian Medical Research University, Faculty of Pediatry, Department of hospital pediatry I.I. Sechenov Moscow State Medical University, Faculty of postgraduate education, Department of Nephrology and Hemodialysis N.F. Filatov Children city hospital No 13, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Chugunova O.L., Shumikhina M.V., Kozlovskaya N.L., Gurevich A.I. Kidney function and blood supply in children with inherited thrombophilia. Nephrology and Dialysis. 2012;14(4):224-235. (In Russ.)
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