Risk factors identification of respiratory tuberculosis progression in patients with end-stage renal disease

Predictor’s study of tuberculosis reactivation among patients with end-stage renal disease (ESRD) is a vital part of recent medical examination for patients who undergo substitution therapy, including candidates for kidney transplantation. In this article, for the first time on a statistically significant sample, we presented the results of studying the relationship between the main clinical and anamnestic risk factors for the development of active tuberculosis in dialysis patients. The analysis of the clinical and anamnestic characteristics of 105 patients with ESRD examined at FSBSI "Central TB Research Institute" with intoxication syndrome of unknown origin and/or newly identified changes in the organs of the chest from 2010 to 2020 was carried out. Based on the results of a comprehensive examination, 62/105 of ESRD patients (59%), were diagnosed with tuberculosis infection -respiratory diseases of non-tuberculous etiology - 43/105 people (41%). The following data were analyzed: the patient's age and sex, the patient's body mass index, the etiology of kidney disease, the presence of treatment for kidney disease before substitution therapy, nephrectomy in the anamnesis, the period of receiving primary substitution therapy, the presence of concomitant pathology, the type of concomitant pathology, tuberculosis history, the period from the onset of uremia before the development of respiratory diseases and their correlation with the etiology of the respiratory diseases, identified based on the results of examination at FSBSI "Central TB Research Institute". It was found that even though, according to various authors, previously such factors as gender, the cause of uremia, and the duration of substitution therapy were identified as predictors of the development of tuberculosis in patients on dialysis, now none of the studied signs has a statistically significant correlation with etiology of respiratory diseases in patients on dialysis. Regardless of gender, age, body mass index (BMI), the cause of renal failure, the number of concomitant diseases, and the duration of follow-up, TCKD patients remain at a high risk of developing active tuberculosis

туберкулез органов дыхания, хроническая болезнь почек, гемодиализ, факторы риска, pulmonary tuberculosis, ESRD, hemodialysis, risk factors, diagnosis

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