Role of cyclosporine in treatment of idiopathic glomerulonephritis and lupus nephritis
Abstract
We present the materials published by an international workshop, which examined how cyclosporine fits into the “therapeutic armamentarium” in idiopathic nephrotic syndrome. A unified and integrated approach for the use of cyclosporine in the most common histologic variants of idiopathic nephrotic syndrome and provided recommendations for monitoring of potential side effects is also described. We also present the data from reviews, devoted to the immunosuppressive regimens and the use of cyclosporine in SLE, treatment of lupus nephritis with cyclosporine and recommendations concerning the use of cyclosporine in proliferative and membranous lupus nephritis.
Keywords
идиопатический нефротический синдром,
болезнь минимальных изменений,
фокальный сегментарный гломерулосклероз,
мембранозная нефропатия,
волчаночный нефрит, иммуносупрессивная терапия,
циклоспорин,
idiopathic nephrotic syndrome,
minimal change disease,
focal segmental glomerulosclerosis,
lupus nephritis,
cyclosporine
About the Authors
E. V. Zakharova
ГУЗ г. Москвы Городская клиническая больница имени С.П. Боткина; кафедра нефрологии МГМСУ
Russian Federation
Russian Federation
L. S. Biryukova
ГУЗ г. Москвы Городская клиническая больница № 52; кафедра нефрологии МГМСУ
Russian Federation
Russian Federation
References
1. Cattran D.C., Alexopoulos E., Heering p. et al. Cyclosporine in idiopatic glomerular disease associated with nephritic syndrome: Workshop recommendations // Kidney International. 2007. Vol. 72. P. 1429–1447.
2. Moroni G., Doria A., Ponticelli C. Cyclosporine (CsA) in lupus nephritis: assessing the evidence // NDT. 2009. Vol. 24. P. 15–20.
3. Ntali S., Tzanakakis M., Bertsias G. et al. What’s New in Clinical Trials in Lupus // Int J Clin Rheum. 2009. Vol. 4. P. 473–485.
Review
For citations:
Zakharova E.V., Biryukova L.S. Role of cyclosporine in treatment of idiopathic glomerulonephritis and lupus nephritis. Nephrology and Dialysis. 2010;12(2):126-141. (In Russ.)
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